Relationship of rheumatoid factor positivity to prevalence of joint manifestations in type 2 diabetes which are unrelated to rheumatoid arthritis
Keywords:
Diabetes mellitus, Rheumatoid factor, Joint manifestationsAbstract
Background: The present study was designed to investigate the relationship of rheumatoid factor positivity to the prevalence of joint manifestations in type 2 diabetes which are not attributable to rheumatoid arthritis.
Methods: We evaluated 192 type 2 diabetes patients with rheumatological complications and age and sex matched non-diabetic controls for rheumatoid factor (RF) positivity. Diabetic patients with frozen shoulder, LJM syndrome, carpal tunnel syndrome, trigger finger, DISH and Dupuytren’s contracture were evaluated for RF positivity.
Results: RF was positive in 47 patients (24.4%) when compared to controls (4.2%). RF positivity was associated with an increased prevalence of joint manifestations in diabetic group when compared to controls. RF positivity was not related to the duration of diabetes nor was it related to long term glycemic control.
Conclusion: RF positivity resulted in an increased prevalence of joint manifestations in diabetes, which were unrelated to rheumatoid arthritis.
References
Oreskes. Spiera H. Rheumatoid factor in rheumatoid arthritis and other diseases. Excerpta Medica Int. Congr. 1967;143:1.
Waaler Erik. On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles. Acta Pathol Microbiol Scand. 2009;17(2):172.
Rose HM. Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis. Ragan Proceedings Society Experiment Biol Med. 1948;68(1):1-6.
Steinbrocker O, Argyros TG. The shoulder-hand syndrome: present status as a diagnostic and therapeutic entity. Med Clin North Am. 1958;42:1533-53.
Jung Y. Hohmann TC, Gerneth JA. Diabetic hand syndrome. Metabolism. 1971;20:1008-15.
Holt PJL. Rheumatological manifestations of diabetes mellitus. Clin Rheum Dis. 1981;7:723-46.
Rosenbloom AL, Silverstein JH, Lezotte DC. Limited joint mobility in childhood diabetes mellitus indicates increased risk for microvascular disease. N Engl J Med. 1981;305:191-4.
Noble J, Heathcote JG, Cohen H. Diabetes mellitus in the aetiology of Dupuytren’s disease. J Bone Joint Surg. 1984;66B:322-5.
Crisp AJ, Heathcoate JG. Connective tissue abnormalities in diabetes mellitus. J R Coll Physicians. 1984;18:132-41.
Lrrwin S. D., Singer J. M. Studies of the incidence and significance of antigamma globulin factors in the aging. Arthr Rheum. 1965;8:538.
Oreskes, H Spiera. Diabetes and rheumatoid factor. Ann Rheum Dis. 1973;32:431-2.
Smith LL, Burnet SP, McNeil JD. Musculoskeletal manifestations of diabetes mellitus. Br J Sports Med. 2003;37(1):30-5.
Lebiedz-Odrobina D, Kay J. Rheumatic manifestations of diabetes mellitus. Rheum Dis Clin North Am. 2010;36(4):681-99.
Liao et al. A specific association exists between type 1 diabetes and antiCCP positive rheumatoid arthritis. Arthritis Rheum. 2009 March;60(3):653-60.
Rosenbloom AL, Silverstein JH. Connective tissue and joint disease in diabetes mellitus. Endocrinol Metab Clin North Am. 1996;25:473-83.
Goldberg BA, Scarlat MM, Harryman DT. Management of the stiff shoulder. J Orthop Sci. 1999;4:462-4-71.
Peter G. Fitzgibbons, Arnold-Peter C. Weiss. Hand manifestations of diabetes mellitus. J Hand Surg. 2008;33A:771-5.
