Study of serum sodium and potassium concentration in cataract patients

Authors

  • Smita A. Deokar Department of Biochemistry, LTMMC and LTMGH, Sion, Mumbai, Maharashtra
  • Pooja S. Rai Department of Biochemistry, LTMMC and LTMGH, Sion, Mumbai, Maharashtra
  • Pramod W. Ingale Department of Biochemistry, LTMMC and LTMGH, Sion, Mumbai, Maharashtra
  • Anita B. Rai Department of Microbiology, B.N. Bandodkar College of Science, Thane, Maharashtra
  • Amruta A. Bakshi Department of Biochemistry, Terna Medical College & Hospital, Mumbai, Maharashtra

Keywords:

Na, K-ATPase, Cataract

Abstract

Background: The present study was aimed to study alterations in levels of sodium and potassium in age-related cataract patients.

Methods: 50 senile cataract patients in age group of 50 to 80 years and 50 control group were included for the study. Serum sodium and potassium levels were determined by flame photometry.

Results: Significant (<0.0001)  increased levels of plasma Na+ in cataract patients (145.06 ± 5.84mEq/lit) were found as compared with controls (141.18 ± 2.67mEq/lit). While Plasma K+ the conc. in cataract patients (4.18 ± 0.34mEq/lit) was not significantly (P = 0.002) increased when compared with controls (4.13 ± 0.32mEq/lit).

Conclusion: Na, K-ATPase is responsible for maintaining the correct concentrations of sodium and potassium in lens cells. In ageing, lens fibers undergoes oxidation, and glycation may decrease Na, K-ATPase activity. The asymmetrical distribution of Na, K-ATPase activity in the epithelium and fibers may contribute to ionic currents that flow in and around the lens. So, abnormal elevation of lens sodium can be used as a marker in the opacification of the lens cortex in age-related human cataract.

References

Ashok V. Katta, Suryakar AN, Katkam RV, Shaikh Kayyum, Santoshi R. Ghodake. Glycation of lens crystalline protein in the pathogenesis of various forms of cataract. Biomed Res. 2009;20(2):119-21.

Hualei Li. Free radicals and cataract. Spring. 2003;222(77):1-23.

Jansirani, P. H. Anathanaryanan. A comparative study of lens protein glycation in various forms of cataract. Indian J Clin Biochem. 2004;19(1):110-2.

Sperduto RD. Epidemiological aspects of age-related cataract. In: Tasman W, Jaeger A, eds. Duane’s. Clinical Ophthalmology. 4th ed. Philadelphia: Lippincott-Raven Publishers; 2000: 3-11.

Mansour Mirsamadi, Issa Nourmohammadi, Manuchehr Imamian. Comparative study of serum Na+ and K+ levels in senile cataract patients and normal individuals. Int J Med Sci. 2004;1(3):165-9.

Luntz MH. Clinical types of cataract. In: Tasman W, Jeager A, eds. Duane’s Clinical Ophthalmology. 4th ed. Philadelphia: Lippincott-Raven Publishers; 2000: 5-7.

Daliles MB, Kinsohita JH. Pathogenesis of cataract. In: Tasman W, Jeager A, eds. Duane’s. Clinical Ophthalmology. 1st ed. Philadelphia: Lippincott-Raven Publishers; 1995: 2-5.

Van Heyningaen R. The Lens: metabolism and cataract. In: Davson H, eds. The Eye. 1st ed. New York: Academic Press; 1961: 380-488.

Donnelly CA, Seth J et al. Some blood plasma constituents correlate with human cataract. Br J Ophthalmol. 1995;79:1036-41.

D. Balasubramanian, Aashish K. Bansal, Surendra Basti et al. The biology of cataract. Indian J Ophthalmol. 1993;41(4):153-71.

Nourmohammadi I, Gohari L, Modarres M, Ghayoumi A. Evaluation of erythrocyte glutathion peroxidase, superoxide dismutase and total antioxidants in cataract patients. Arch Iran Med. 2001;4:123-7.

The Italian-American Cataract Study Group. Risk factors for age-related cortical, nuclear and posterior subcapsular cataracts. Am J Epidemiol. 1991;133:541-4.

Sperduto R, Hiller R. The prevalence of nuclear, cortical and posterior sub-capsular lens opacities in a general population sample. Ophthalmol. 1984;91:815-8.

Clayton RM, Cuthbert J, Phillips CI, Bartholomew RS, Stokoe NL, Fytch T et al. Analysis of individual cataract patients and their lenses: a progress report. Experiment Eye Res. 1980;31:533-6.

Delamere NA, Paterson CA. Crystalline lens. In: Tasman W, Jeager A, eds. Duane’s Foundations of Clinical Ophthalmology. 5th ed. Philadelphia: Lippincott-Raven Publishers; 2001: 5-11.

Phillips CI, Bartholomew RS, Clayton R, Duffy J et al. Cataract: a search for associations or causative factors: Symposium on the Lens. Excerpt Med. 1980;19(1):25.

Paterson CA, Delamere NA. ATPases and lens ion balance. Exp Eye Res. 2004 Mar;78(3):699-703.

Zil’fian AA. Disorders of ion balance in intraocular liquid at patients with senile and complicated cataracts. Georgian Med News. 2013 May;(218):10-5.

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Published

2017-01-23

How to Cite

Deokar, S. A., Rai, P. S., Ingale, P. W., Rai, A. B., & Bakshi, A. A. (2017). Study of serum sodium and potassium concentration in cataract patients. International Journal of Research in Medical Sciences, 2(2), 592–594. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2204

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Section

Original Research Articles