A comparative study of safety and efficacy of tiotropium bromide with salbutamol in moderate persistent bronchial asthma in a tertiary care hospital

Authors

  • Vijaya S Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh
  • Rajyalakshmi N Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh
  • Ramanath B Department of Pharmacology, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka

Keywords:

Tiotropium bromide, Salbutamol, FEV1, FVC, FEV1 / FVC and moderate persistent asthma

Abstract

Background: The objective of this study was to compare the safety and efficacy of tiotropium bromide with salbutamol in moderate persistent cases of bronchial asthma at tertiary care hospital.

Methods: This was an open label, randomized parallel group study done in Government General Hospital, Srikakulam for a period of 12 weeks. Group-1 was given tiotropium bromide metered dose inhalational therapy 18mcg once daily in 50 patients. Group-2 was given salbutamol metered dose inhalational therapy 100mcg thrice daily in 30 patients.

Results: Symptomatic improvement was observed in l two groups. At end point, mean FEV1 in tiotropium bromide treatment group improved by 149.96% compared with 135.16% salbutamol treatment group. At end point, mean FVC value in tiotropium bromide treatment group improved by 145.71% compared with 122.34% in salbutamol group. Mean FEV1 / FVC also improved by 155.41% in tiotropium bromide group compared with 105.41 % in salbutamol group.

Conclusion: The present study proved tiotropium provide superior safety and efficacy relative to control drug in bronchial asthma patients in both clinical assessment score and spirometrically.

 

References

Sharma HL, Sharma KK, principles of pharmacology, 1st edition 2007; 50: pp 658.

Harrison’s Principles of Internal Medicine, 17th edition 2010, p 02-08.

World Health Organization fact sheet No.307; Asthma 2009, Retrieved 2nd Sept.2010.

Subbarao P, Mandhane PJ, Sears MR. Asthma: Epidemiology, etiology and risk factors. CMAJ 2009; 181: E181-90.

Raphael GD, Lanier RQ, Baker J, Edwards L, Richard K, Lincourt WR. A comparison of multiple doses of fluticasone propionate and beclomethasone dipropionate in subjects with persistent asthma. J Allergy Clin Immunol. 1999; 103: 796-803.

Louis R, Lau LCK, Bron AO, Rodaan AC, Radermecker M, Djukanovic R. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med. 2000; 161: 9-16.

Asthma Allergy & Airway Research Center [homepage on the Internet]. Information for Health Care Professionals. Asthma assessment [cited 2003 Mar 20]. Available from: http://www.upmc.edu/ AAARC/professionals.htm.

H. Iwamote, A.Yokayama, N. Shiota, H.Shoda, Y. Haruta, N. Hattori and N. Kohno. Tiotropium bromide is effective for severe Asthma with non oesinophilic phenotype. Eur.Resp.J., June 1,2008, 31 (6): 1379-80.

BJ O’Connor, LJ Towse, PJ Barnes. Clinical srudies unit, Royal Brompton National Heart and Lung Hospital, American Journal of Respiratory and Critical care medicine London, UK Vol 154; No.4, Oct 1996 : 876-80.

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Published

2017-01-26

How to Cite

S, V., N, R., & B, R. (2017). A comparative study of safety and efficacy of tiotropium bromide with salbutamol in moderate persistent bronchial asthma in a tertiary care hospital. International Journal of Research in Medical Sciences, 2(4), 1479–1482. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2444

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Original Research Articles