Incidence of bone tumors and tumor like lesions at a tertiary centre - a study of 64 cases

Authors

  • Nidhi Verma Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • Amit Tyagi Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • Preeti Singh Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • Meenakshi Tyagi Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, India
  • Monika Rathi Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • S. P. Sharma Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, Indiaia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20180293

Keywords:

Aspiration cytology, Bone tumors, Demographic profile, Tumor like lesions

Abstract

Background: Primary bone tumors are uncommon lesions constituting less than 1% of all cancers. Although open biopsy has high accuracy, it increases risk of tumor dissemination in patients with highly malignant tumors. FNAC eliminates the complications that may occur in surgical procedures and also gives quick results. This study was conducted to determine the spectrum and demographic characteristics of bone tumors and tumor like lesions at a tertiary care centre in western Uttar Pradesh and also to assess the role of FNAC in their diagnosis.

Methods: This is a three-year, retrospective as well as a prospective study done on a total of 64 cases. All the cases were subjected to detailed history, physical examination and radiological investigations. FNAC smears were stained with Giemsa and Papanicolaou stain. H and E staining was done for histopathology.

Results: Mean age affected was 26 years. Male-female ratio was 2.8:1. Out of total 64 cases of bone tumors and tumor like lesions, maximum was chondrogenic tumors (17; 26.56%), followed by osteogenic tumors (15; 23.44%). Osteochondroma (08; 47.06%), Osteosarcoma (07; 46.66%) and Aneurysmal bone cyst (04; 50.0%) were the most common chondrogenic tumor, osteogenic tumor and tumor like lesion respectively. The most common bone affected was tibia (16; 25.0%), followed by femur (15; 23.4%). Sensitivity and specificity of FNAC as a diagnostic modality were 90.0% and 91.67% respectively.

Conclusions: A good correlation is observed between cytological and histological diagnoses which implies that FNAC can be used as a preliminary diagnostic approach to bone tumors, although histopathology remains the gold standard.

References

Dorfman HD, Czerniak B. Bone cancers. Cancer. 1995;75:203-10.

Yeole BB, Jussawalla DJ. Descriptive epidemiology of bone cancer in greater Bombay. Indian J Cancer. 1998;35(3):101-6.

Katchy KC, Ziad F, Alexander S, Gad H, Abdel Mota'al M. Malignant bone tumors in Kuwait: a 10-year clinicopathological study. Int Orthop. 2005;29(6):406-11.

Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, et al. SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/, based on November 2015 SEER data submission, posted to the SEER web site, April 2016.

Roskell DE, Buley ID. Fine needle aspiration cytology in cancer diagnosis. BMJ. 2004;329 (7460):244-5.

Negash BE, Admasie D, Wamisho BL, Tinsay MW. Bone tumors at Addis Ababa University, Ethiopia: Agreement between radiological and histopathological diagnoses, a 5-year analysis at Black-Lion Teaching Hospital. Internat J Medic and Medic Sci. 2009; 1(4): 119-125.

Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital. JKIMSU. 2015;4:2.

Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, et al. Spectrum of Bone Tumors in Chiang Mai University Hospital, Thailand According to WHO Classification 2002: A Study of 1,001 Cases. J Med Assoc Thai. 2006;89:6.

Link TM, Brinkschmidt C, Lindner N, Wörtler K, Heindel W. Primary bone tumors and "tumor-like lesions" of the shoulder. Their histopathology and imaging. Rofo. 1999;170(5):507-13.

Baena-Ocampo Ldel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R. Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol. 2009;13(1):16-21.

Jain K, Sunila, Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB, Manjunath GV. Bone tumors in a tertiary care hospital of south India: A review 117 cases. Indian J Med Paediatr Oncol. 2011;32(2):82-5.

Solooki S, Vosoughi AR, Masoomi V. Epidemiology of musculoskeletal tumors in Shiraz, south of Iran. Ind J Med Paediatr Oncol. 2011; 32:187-91.

Hathila RN, Mehta JR, Jha BM, Saini PK, Dudhat RB, Shah MB. Analysis of bone lesions in tertiary care center - A review of 79 cases. Int J Med Sci Public Health. 2013;2:1037-040.

Wani LA, Ashai FB, Banday BM, Ashraf A, Mushtaq S, Itoo MS, et al. Primary Bone tumours in Kashmir valley- a retrospective histopathological study. Internat J Basic Applied Sci. 2015;4(1):51-6.

Patel D, Patel P, Gandhi T, Patel N, Patwa J. Clinicopathological study of bone lesions in tertiary care center - a review of 80 cases. International Journal of Advanced Research. 2015;3(7):1267-72.

Sharma S and Mehta NP. Histopathological Study of Bone Tumors. Internat J Sci Res. 2015;4(12): 1970-2.

Özkan EA, Göret CC, Özdemir ZT, Yanık S, Doğan M, Gönültaş A, et al. Pattern of primary tumors and tumor-like lesions of bone in children: retrospective survey of biopsy results. Int J Clin Exp Pathol. 2015;8(9):11543-8.

Ramdass MJ, Mooteeram J, Beharry A, Mencia M, Barrow S. An 8-YEAR analysis of bone tumours in a Caribbean island. Annals of Medic Surg. 2015;4:414-6.

Rhutso Y, Laishram RS, Sharma LD, Debnath K. Histopathological evaluation of bone tumors in a tertiary care hospital in Manipur, India. J Med Soc. 2013;27:135-9.

Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological study of bone lesions - A review of 102 cases. IAIM. 2016;3(4):27-36.

Rao VS, Pai MR, Rao RC, Adhikary MM. Incidence of primary bone tumours and tumour like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Assoc. 1996;94(3):103-4.

Puthur DK. Tumour like lesions: Understand the difference. Kerala J Orthopaed. 2013;137-42.

Oommen AT, Madhuri V, Walter NM. Benign tumors and tumor-like lesions of the calcaneum: A study of 12 cases. Ind J Cancer. 2009;46(3):234-6.

Estrada-Villaseñor EG, Flores-Carmona JF, Delgado-Cedillo EA, Rico-Martínez G. Bone tumor frequency in adults and elderly. Acta Ortop Mex. 2008;22(6):356-60.

Popat V, Sata V, Vora D, Bhanvadia V, Shah M, Kanara L. Role of Histopathology In Lytic Lesions Of Bone - A Study Of Seventy Cases Of Lytic Lesion Of Bone. The Internet J Orthopedic Surg. 2010;19:1.

Kundu ZS, Gupta V, Sangwan SS, Rana P. Curettage of benign bone tumors and tumor like lesions: A retrospective analysis. Indian J Orthop. 2013;47(3):295-301.

Vijayaraghavan L, Lailaraji N, Gopakumar TS, Roy N, Radhakrishnan N. Lytic Lesions of Bone: A Histopathological and Radiological Correlative Study. Academic Medic J Ind. 2015;3(3):83-7.

Van den Berg H, Kroon HM, Slaar A, Hogendoorn P. Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA". J Pediatr Orthop. 2008; 28(1):29-35.

Mohammed A, Sani MA, Hezekiah IA, Enoch AA. Primary bone tumours and tumour-like lesions in children in Zaria, Nigeria. Afr J Paediatr Surg. 2010; 7:16-8.

Bommer KK, Ramzy I, Mody D. Fine-needle aspiration biopsy in the diagnosis and management of bone lesions: a study of 450 cases. Cancer. 1997; 81:148-56.

Soderlund V, Skoog L, Kreicbergs A. Combined radiology and cytology in the diagnosis of bone lesions: a retrospective study of 370 cases. Acta Orthop Scand. 2004;75(4):492-9.

Nnodu OE, Giwa SO, Eyesan SU, Abdulkareem FB. Fine needle aspiration cytology of bone tumours – The experience from the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria. Cyto J. 2006;3:16.

Chakrabarti S, Datta AS, Hira M. Critical Evaluation of Fine Needle Aspiration Cytology as a Diagnostic Technique in Bone Tumors and Tumor-like Lesions. Asian Pacific J Cancer Prev. 2012;13: 3031-5.

Rajani M, MeherPrasanna R, Sailabala G, Padmavathi Devi C. Fine Needle Aspiration Cytological study of Bone tumors and tumor like lesions with clinic pathological correlation. IOSR J Pharmac Biologic Sci. 2014;9(4-II):130-42.

Nirmala C, Patil P, Sejekin SV, Raghupathi AR. Technical challenges and spectrum of lesions in fine needle aspiration cytology of bone lesions. Int J Cur Res Rev. 2014;06(14):25-31.

Devi S, Dey S, Chakrabarty PS. Role of fine needle aspiration cytology as an initial diagnostic tool in musculoskeletal tumours. Ind J Medic Res Pharmaceutic Sci. 2015;2(6):1-10.

Mahajan S, Saoji AA, Agrawal A. Utility of Fine Needle Aspiration Cytology in Diagnosing Bone Tumors. Cancer Transl Med. 2015;1(5):166-9.

Mehrotra R, Singh M, Singh PA, Mannan R, Ojha V K, Singh P. Should fine needle aspiration biopsy be the first pathological investigation in the diagnosis of a bone lesion? An algorithmic approach with review of literature. Cyto J. 2007;4:9-18.

Hasan SM, Ahmad S, Akhtar K, Hasan J, Abbas M, Ahmad I. Percutaneous Needle Biopsy-An Assertive Tool In The Diagnosis of Bone Tumors in Under Developed Countries. JK Science. 2012;4:4.

Kujur P, Kosam S. Fine Needle Aspiration Cytological Study of Bone Tumors and Tumor-like Lesions: A Review of Cases with Cytological-histopathological Correlation. Int J Sci Stud. 2016;4(2):214-9.

Downloads

Published

2018-01-24

How to Cite

Verma, N., Tyagi, A., Singh, P., Tyagi, M., Rathi, M., & Sharma, S. P. (2018). Incidence of bone tumors and tumor like lesions at a tertiary centre - a study of 64 cases. International Journal of Research in Medical Sciences, 6(2), 533–538. https://doi.org/10.18203/2320-6012.ijrms20180293

Issue

Section

Original Research Articles