DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20213932

Correlation between atherogenic index of plasma and national institutes of health stroke scale score in acute ischemic stroke patients at Haji Adam Malik general hospital, Medan

Muhammad Zulfikri, Cut A. Arina, Chairil A. Batubara

Abstract


Background: Stroke is the leading cause of morbidity and mortality in Indonesia. Dyslipidemia is one of the main risk factors of ischemic stroke. Atherogenic index of plasma (AIP) is the logarithm of the triglyceride’s plasma ratio concentration to high density lipoprotein cholesterol (HDL-C) plasma concentration. Previous studies showed that the high AIP at hospital admission was associated with deterioration of neurological deficits in patients with acute ischemic stroke.

Methods: This is a cross sectional study with 82 sample of acute ischemic stroke subjects that consecutively collected from the medical records of Haji Adam Malik general hospital Medan from January to December 2019, AIP assessment performed at the 1st day of hospitalization and then at the 7th -onset the national institutes of health stroke scale (NIHSS) score assessment was count. Data analysis is conducted with Spearman test.

Results: Demographic characteristics showed that most subjects were female (51.2%), at age range between 60 -68 years (30.5%), had high school education level (48.8%), self-employed (35.4%) and Bataknese (68.3%). The mean of AIP was 0.15±0.26 and the mean NIHSS score was 6.70±3.6. There was a positive significant and mild power of correlation between AIP and the NIHSS score (p=0.017; r=0.262).

Conclusions: There is a significant relationship between AIP and the NIHSS score. The higher the AIP of acute ischemic stroke patients was associated with the increase in the NIHHS scores.

 


Keywords


AIP, NIHSS, Acute ischemic stroke

Full Text:

PDF

References


Sacco RL, Kasner SE, Broderick JP, Caplan LR, Culebras A, Elkind M et al. An Update Definition of Stroke for 21st Century: Professionals from The American Association/American Stroke Association. Stroke. 2013;40:2064-89.

RISKESDAS (Riset Kesehatan Dasar). Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan R.I Tahun. 2018;2018.

Misbach J, Dan Soertidewi L. Stroke Aspek Diagnostik, Patofisiologi, Manajemen. Soertidewi L, Jannis J. Jakarta Badan Penerbit FK UI. 2011;Hal:21-9.

Boehme AK, Esenwa C, Elkind MS. Stroke risk factors, genetics, and prevention. Circulation res. 2017;120(3):472-95.

Soška V, Jarkovský J, Ravčuková B, Tichý L, Fajkusová L, Freiberger T. The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia. Clin biochem. 2012;45(1-2):96-100.

Sujatha R, Kavitha, S. Atherogenic indices in stroke patients: A retrospective study. Iranian j neurol. 2017;16(2):78-82.

Finocchi C, Balestrino M, Malfatto L, Mancardi G, Serrati C, Gandolfo C. National Institutes of Health Stroke Scale in patients with primary intracerebral hemorrhage. Neurol Sci. 2018;39(10):1751-5.

Park JH, Lee J, Ovbiagele, B. Nontraditional serum lipid variables and recurrent stroke risk. Stroke. 2014;45(11):3269-74.

Mianoki A, Gofir A, Dan Nuradyo D. Korelasi antara indeks aterogenik plasma dengan derajat defisit neurologis pasien stroke iskemia akut. Berkala Neuro Sains. 2017;18(3):142-7.

Rambe AS, Fithrie A, Nasution I, Dan Tonam. Profil Pasien Stroke pada 25 Rumah Sakit di Sumatera Utara 2012, Survei Berbasis Rumah Sakit. Neurona. 2013;30(2).

Apriani N, Sinurat PPO, Kadri A. Changes in platelet aggregation and nihss after anti-platelet therapy for acute ischemic stroke patients at Adam malik general hospital Medan. Education. 2020;18(20):47-4.

Yolanda IR, Surbakti KP, Kadri A. Association between blood pressure variability and early neurological deterioration in acute ischemic stroke patients. Education. 2020;22(18):55.

Reilly MR, McCullough LD. Age and Sex Are Critical Factors in Ischemic Stroke Pathology. Endocrine Society. 2018;1-22.

Goldstein LB, Cheryl DB, Robert JA, Lawrence JA, Lynne TB, Seemant C et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/ American Stroke Association. Stroke. 2011;42(2):517-84.

Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(5):1545-88.

Lisabeth L, Bushnel L. Menopause and stroke: an epidemiologic review. Lancet neurol. 2012;11(1):82.

WHO. Research on The Menopause. Geneva: WHO Scientific Group. 2014.

Addo J, Ayerbe L, Mohan KM, Crichton S, Sheldenkar A, Chen R et al. Socioeconomic status and stroke: an updated review. Stroke. 2012;43(4):1186-91.

Nainggolan T, Pasaribu JB, Simanjuntak MSE, Dan Simorangkir MSE. Karakter Batak: Masa Lalu, Kini, dan Masa Depan. Jakarta. Yayasan Pustaka Obor Indonesia. 2015;xvi:239.

Manurung M, Diani N, Dan Agianto. Analisa Faktor Risiko Stroke pada Pasien Stroke Rawat di RSUD Banjarbaru. J DK. 2015;3(1):74-85.

Arisoy YM, Maja J, Dan Runtumene T. Gambaran NIHSS pada Pasien Stroke di Ruang Rawat Inap Neurologi RSUP Prof. Dr. RD Kandou Manado periode Juli 2014-Juni 2015. e-Clinic. 2016;4:1.

Soliman RH, Oraby MI, Fathy M, Essam AM. Risk factors of acute ischemic stroke in patients presented to Beni-Suef University Hospital: prevalence and relation to stroke severity at presentation. Egypt j neurol, psychiatry neurosurg. 2018;54(1):1-9.