Prevalence of retinopathy of prematurity: a 3-year retrospective study

Aval S. Patel, Rishi Mehta


Background: Retinopathy of prematurity (ROP) is a vasoproliferative disease of premature infants which leads to permanent blindness. Early screening is needed to diagnose ROP and prevent blindness.

Methods: Retrospective study was conducted in 225 neonates from January 2018 to December 2020. All neonates with birth weight <2000 gm and/or gestational age <38 weeks were included. History of oxygen given to neonates and presence of sepsis in neonates was noted. The infant’s pupil were dilated. Fundus examination was done. All the data was entered in MS-Excel 2016 and analyzed by SPSS (version 19). Chi-square test was done to calculate p value.

Results: Out of total of 225 neonates, 137 (60.88%) were males and 88 (39.12%) were females. The gestation age of neonates (in weeks) ranged from 25 to 40 (mean: 32.35). The birth weight of neonates (in grams) ranged from 570 to 2500 (mean: 1460). 21 (9.33%) were found to have ROP. The male neonates found with ROP were 16 (11.67%) while females were 5 (5.68%) (p>0.05). Out of 148 neonates who were given oxygen 19 (12.83%) developed ROP (odds ratio: 5.52). Out of 42 neonates who had sepsis, 2 (4.76%) developed ROP (odds ratio: 0.43).

Conclusions: The prevalence of ROP was 9.33%. The prevalence is showing a decreasing trend. ROP is not affected by gender. Oxygen given to neonates is associated with greater ROP. But sepsis in neonates is not associated with development of ROP.


Oxygen, Prevalence, Retinopathy of prematurity, Sepsis

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Huang J, Tang Y, Zhu T, Li Y, Chun H, Qu Y, et al. Cumulative evidence for association of sepsis and retinopathy of prematurity. Medicine. 2019;98(42).

Kim SJ, Port AD, Swan R, Campbell JP, Chan RP, Chiang MF. Retinopathy of prematurity: a review of risk factors and their clinical significance. Survey Ophthalmol. 2018;63(5):618-37.

Freitas AM, Mörschbächer R, Thorell MR, Rhoden EL. Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study. Int J Retina Vitreous. 2018;4(1):20.

Beharry KD, Valencia GB, Lazzaro DR, Aranda JV. Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity. Semin Perinatol. 2016;40(3):189-202.

Le C, Basani LB, Zurakowski D, Ayyala RS, Agraharam SG. Retinopathy of prematurity: Incidence, prevalence, risk factors, and outcomes at a tertiary care center in Telangana. J Clin Ophthalmol Res. 2016;4(3):119.

Bolton DP, Cross KW. Further observations on the cost of preventing retrolental fibroplasia. Lancet. 1974;1(7855):445-8.

Celebi AR, Petricli IS, Hekimoglu E, Demirel N, Bas AY. The incidence and risk factors of severe retinopathy of prematurity in extremely low birth weight infants in Turkey. Med Sci Monitor Int Med J Experiment Clin Res. 2014;20:1647.

Wu T, Zhang L, Tong Y, Qu Y, Xia B, Mu D. Retinopathy of prematurity among very low-birth-weight infants in China: incidence and perinatal risk factors. Investig Ophthalmol Visual Sci. 2018;59(2):757-63.

Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singapore. 2005;34(2):169-78.

Seiberth V, Linderkamp O. Risk factors in retinopathy of prematurity. Ophthalmologica. 2000;214(2):131-5.

Nikhil R, Rajendran K, Krishnan B. Prevalence and outcome of retinopathy of prematurity in preterm infants, with low birth weight at KMCH, Tamil Nadu, India. Int J Contemp Pediatr. 2019;6(2):264.

Hakeem AH, Mohamed GB, Othman MF. Retinopathy of prematurity: a study of prevalence and risk factors. Middle East Afr J Ophthalmol. 2012;19(3):289.

Dwivedi A, Dwivedi D, Lakhtakia S, Chalisgaonkar C, Jain S. Prevalence, risk factors and pattern of severe retinopathy of prematurity in eastern Madhya Pradesh. Indian J Ophthalmol. 2019;67(6):819.

Lermann VL, Fortes Filho JB, Procianoy RS. The prevalence of retinopathy of prematurity in very low birth weight newborn infants. Jornal de Pediatria. 2006;82:27-32.

Dalai R, Das K, Nayak D, Murmu MC, Nanda PK. A clinical study on retinopathy of prematurity in a tertiary care centre. Int J Res Med Sci. 2019;7(11):4181.

Mehta R, Punjabi S, Jain R, Bedi N, Nagar CK. Prevalence of retinopathy of prematurity at tertiary care centre in Southern Rajasthan. Indian J Clin Experiment Ophthalmol. 2017;3(2):147-9.

Chen M, Çitil A, McCabe F, Leicht KM, Fiascone J, Dammann CE, et al. Infection, oxygen, and immaturity: interacting risk factors for retinopathy of prematurity. Neonatology. 2011;99(2):125-32.

Murthy KR, Nagendra BK. Analysis of risk factors for the development of ROP in preterm infants at a tertiary referral hospital in South India. Acta Medica Lituanica. 2006;13:147-51.

Weinberger B, Laskin DL, Heck DE, Laskin JD. Oxygen toxicity in premature infants. Toxicol Appl Pharmacol. 2002;181(1):60-7.

Hartnett ME, Lane RH. Effects of oxygen on the development and severity of retinopathy of prematurity. J Am Assoc Pediatr Ophthalmol Strabismus. 2013;17(3):229-34.

Flynn JT, Bancalari E, Snyder ES, Goldberg RN, Feuer W, Cassady J, et al. A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity. N Engl J Med. 1992;326(16):1050-4.

Liu PM, Fang PC, Huang CB, Kou HK, Chung MY, Yang YH, et al. Risk factors of retinopathy of prematurity in premature infants weighing less than 1600 gm. Am J Perinatol. 2005;22(02):115-20.

Manzoni P, Maestri A, Leonessa M, Mostert M, Farina D, Gomirato G. Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates. J Perinatol. 2006;26(1):23-30.