DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20214419

Study of lipids and lipoprotein levels in uncomplicated diabetes mellitus patients attending Shadan hospital

Samatha Tulla, Syeda Ayesha Siddiqua

Abstract


Background: Lipid and lipoprotein levels are interrelated with diabetes mellitus. Abnormalities in the levels of total cholesterol (TC) or triglycerides (TAG) or low-density lipoprotein (LDL) cholesterol or very-low-density lipoprotein (VLDL) cholesterol or high-density lipoprotein (HDL) cholesterol or lipoprotein (a) [Lp (a)] is traditionally named as dyslipidemia. Diabetes mellitus has been known to be associated with lipid disorders and cardiovascular diseases. In patients with diabetes mellitus, dyslipidemia occurs earlier in life, leading to increased morbidity and mortality rates. The study aims to assess the changes in lipids and lipoprotein levels in uncomplicated diabetes mellitus patients.

Methods: A case-control type of study was conducted for 18 months (September 2011 to March 2013) at the Department of General Medicine, Shadan Hospital, Hyderabad. Ethical committee approval was taken before the study from the institutional ethical committee. A total of 120 subjects, 60 non-diabetic (healthy) control subjects with matching age and gender and, 60 cases of subjects with uncomplicated diabetes mellitus were enrolled based on predetermined inclusion and exclusion criteria.

Results: This study was conducted to evaluate the changes in lipids and lipoprotein levels between control (normal and healthy subjects) and case (subjects with uncomplicated diabetes mellitus) groups. The Mean±SD levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and lipoprotein (a) were higher in the cases group and showed statistical significance when compared with the control group.

Conclusions: Our study states that there are abnormal levels of lipids and lipoprotein in subjects with uncomplicated diabetes mellitus, which is the foremost cause of cardiovascular diseases, coronary heart disease, dyslipidemia, etc.


Keywords


HDL, LDL, Lipid, Lipoprotein, Lp(a), TAG, TC, Uncomplicated diabetes mellitus, VLDL

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References


Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.

Brancati FL, Kao WHL, Folsom AR, Watson RL, Szklo M. Incident type 2 diabetes mellitus in African American and white adults: The atherosclerosis risk in communities study. J Am Med Assoc. 2000;283(17).

Dailey GE, Mohideen P, Fiedorek FT. Lipid effects of glyburide/metformin tablets in patients with type 2 diabetes mellitus with poor glycemic control and dyslipidemia in an open-label extension study. Clin Ther. 2002;24(9).

Chattanda S, Mgonda Y. Diabetic dyslipidemia among diabetic patients attending specialized clinics in Dar es Salaam. Tanzania Med J. 2008;23(1).

Watson KE, Horowitz BN, Matson G. Lipid abnormalities in insulin resistant states. Rev Cardiovasc Med. 2003;4(4).

Tipping RW, Ford CE, Simpson LM, Walldius G, Jungner I, Folsom AR, et al. Lipoprotein (a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA J Am Med Assoc. 2009;302(4).

Oliver J. Guidelines for the prevention, management and care of diabetes mellitus. J Chem Inf Model. 2013;53(9):1689-99.

Inada A, Weir GC, Bonner-Weir S. Induced ICER Iγ down-regulates cyclin a expression and cell proliferation in insulin-producing β cells. Biochem Biophys Res Commun. 2005;329(3):925-9.

Shankarprasad DS, Gundalli S, Mahantesh B, Kashinakunti SV, Sunitha P. Lipid profile in diabetes mellitus. Indian J Pathol Oncol. 2015;2(4):290-4.

Bruckert E, Davidoff P, Grimaldi A, Truffert J, Giral P, Doumith R, et al. Increased serum levels of lipoprotein(a) in diabetes mellitus and their reduction with glycemic control. JAMA J Am Med Assoc. 1990;263(1):35-6.

Yeğin A, Özben T. Serum glycated lipoproteins in type II diabetic patients with and without complications. Ann Clin Biochem. 1995;32(5):459-63.

Bitzur R, Cohen H, Kamari Y, Shaish A, Harats D. Triglycerides and HDL cholesterol: stars or second leads in diabetes? Diabetes Care. 2009;32(2):373-7.

Zabeen B, Balsa AM, Islam N, Parveen M, Nahar J, Azad K. Lipid profile in relation to glycemic control in Type 1 diabetes children and adolescents in Bangladesh. Indian J Endocrinol Metab. 2018;22(1).

Biadgo B, Abebe SM, Baynes HW, Yesuf M, Alemu A, Abebe M. Correlation between serum lipid profile with anthropometric and clinical variables in patients with type 2 diabetes mellitus. Ethiopian J Health Sci. 2017;27(3):215-26.

Pant DC, Mowar AB, Chandra N. Co-relation between total cholesterol, high density lipoprotein, low density lipoprotein and glycosylated haemoglobin (HbA1c) in diabetic patients with acute coronary syndrome (ACS). J Assoc Phys India. 2018;66(July):1-5.