Chronic myeloid leukemia on imatinib with recurrent sub-dural haemorrhage

Ambati Bhavani, Palanki Satya Dattatreya, Vinukonda Shyamala


Imatinib is an FDA approved first-line treatment for Philadelphia-positive CML. It is a selective tyrosine kinase inhibitor specifically targeting BCR-ABL, c-KIT, PDGFRA. It has been reported with low incidence of adverse effects and high tolerability, with haemorrhagic events being a rare complication. We report here a case of 51-year-old female patient with chronic myeloid leukemia who was on high dose imatinib experienced recurrent sub-dural haemorrhage. This case report emphasizes on the need to consider Sub dural haemorrhage as an unusual cause of headache associated with vomiting in a patient taking high dose of imatinib.


Chronic myeloid leukemia, Imatinib, Subdural hemorrhage

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