Guillain-Barré syndrome associated with COVID- 19 vaccination: a case report

Authors

  • Vinod John Department of General Medicine, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India
  • Jiya Thankam Koshy Department of Neurology, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India
  • Nikhil Gladson Department of Neurology, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India
  • Vimod K. Wills Department of General Medicine, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20215064

Keywords:

Guillain-Barre syndrome, COVID-19 vaccine, AIDP, ChAdOx1-n-CoV-19, Covishield

Abstract

Several reports and studies are being conducted to this day based on the safety profile of COVID-19 vaccines. COVID-19 vaccination inducing GBS is a rare adverse effect and is likely to be causal. Though, there are reports concerning the relation between coronavirus infections and GBS, the pathogenic mechanism and relevant factors behind COVID-19 vaccines inducing GBS are still not being corroborated so far. Guillain-Barre syndrome is the principal cause of acute flaccid paralysis with a prevalence rate of 2 in 100, 000 people per year. We illustrate a 55 years old female patient who presented with acute onset paraesthesia and progressive weakness of bilateral lower limbs and gait imbalance of 5 days duration to the Hospital during the first week of September. Her symptoms occurred within 2 weeks of the first dose of the ChAdOx1-n-CoV-19 (Covishield) vaccine proving a major possibility of vaccine-induced neurological adverse effect as she didn't have any likely significant history of illness or allergies in the past rather than type 2 diabetes mellitus. This report aims to highlight the incidence and to ruminate upon this matter while evaluating any GBS cases in the current eras of the COVID-19 pandemic and vaccination.

Author Biographies

Vinod John, Department of General Medicine, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India

Consultant Physician, Department of General Medicine

Jiya Thankam Koshy, Department of Neurology, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India

Neurology Clinical Pharmacist, Department of Neurology

Nikhil Gladson, Department of Neurology, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India

Consultant Neurologist, Department of Neurology

Vimod K. Wills, Department of General Medicine, Tiruvalla Medical Mission Hospital, Thiruvalla, Kerala, India

Consultant Physician, Department of General Medicine

References

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Published

2021-12-28

How to Cite

John, V., Koshy, J. T., Gladson, N., & Wills, V. K. (2021). Guillain-Barré syndrome associated with COVID- 19 vaccination: a case report. International Journal of Research in Medical Sciences, 10(1), 268–272. https://doi.org/10.18203/2320-6012.ijrms20215064

Issue

Section

Case Reports