Clinico-hematological study of leukemias in a hospital-based setup
Keywords:Leukemia, AML, CML, ALL, CLL
Background: Leukemia, the malignant proliferation of hematopoietic cells, accounts for a major portion of cancer globally. Types of leukemia are necessary for effective therapy as prognosis, and survival rates are different for each type of leukemia. The objective of the study was to know the relative incidence of leukemia in Silchar Medical College and Hospital, Assam. This study also aims to know the clinical manifestations of leukemia and their hematological correlation.
Methods: It was a retrospective study of 60 patients carried out in the Department of Pathology in SMCH, Assam, over a period of 2 years from April 2019 to March 2021. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination for morphology, along with cytochemistry study whenever required.
Results: In this study, acute leukemia was more prevalent than chronic leukemia. The most common form was CML followed by AML, ALL and then CLL. Male predominance was observed in this study with male: female ratio = 1.7:1.
Conclusions: In our study, Acute leukemia was more prevalent than chronic leukemia. Leukemia affected male more than female. In this study, the frequency of AML is more than that of ALL but number of cases of CML exceeds that of AML.
Kawthalkar SM. Essentials of Hematology, 3rd Edition. Jaypee Brothers Medical Publications.1998;235.
Stewart BW, Kleihues P, editors. World cancer report. IARC. 2003;12:112-4.
Prakash S, Murti R, Rana G, Aurora AI. Leukemias at Pondicherry, Indian J cancer 1981;18:1-6.
Gralnick HR, Galton DA, CATOVSKY D, SULTAN C, BENNETT JM. Classification of acute leukemia. Annals of Internal Medicine. 1977 Dec 1;87(6):740-53.
Gunz FW. The epidemiology and genetics of chronic leukemias. Clinical Haematology. 1977;6:3-20.
Gajender S, Padam P. International Journal of Research in Medical Sciences. Int J Res Med Sci. 2016;4(4):1115-8.
Nasim NN, Malik K, Mobeen NA, Awan S, Maz N. Investigation on the prevalence of Leukaemia at a tertiary care hospital, Lahore. Biomedica. 2013;29(1):19-22.
Jatav J, Jain B, Niranjan AK. Clinicopathological study of acute lymphoblastic leukemia-a multiparameter study. Cough. 2015;2:5-4.
Baviskar JB. Incidence of acute and chronic leukemias in rural area at tertiary care teaching hospital: a five years of study. Indian Journal of Pathology and Oncology. 2016;3(4):710-3.
PS V, DP M. Clinical studies in leukemia--review of 100 cases. The Journal of the Association of Physicians of India. 1962;10:677-82.
Kushwaha MR, Bagchi M, Mehrotra RM. Leukaemias at Lucknow--a study of 200 cases. Indian journal of cancer. 1978;15(3):28-34.
Chatterji JB, Ghose S, Ray RN. Incidence of leukaemia. An analysis of 544 cases studied in Calcutta. The Journal of the Association of Physicians of India. 1962;10:673-6.
Hamayun M, Khan SA, Muhammad W. Investigation on the prevalence of leukemia in North West Frontier Province of Pakistan. Turkish journal of cancer. 2005;35(3).
Ali L, Sharif S, Zaidi A. Incidence and Clinical Profile of Leukemia in Children. Journal of Postgraduate Medical Institute (Peshawar-Pakistan). 1999;13(2).
Yasmeen N, Ashraf S. Childhood acute lymphoblastic leukaemia; epidemiology and clinicopathological features. JPMA. 2009;59(150).
Shome DK, Ghosh K, Mohanty D, Das KC. Leukaemia in north-west India. Acta haematologica. 1985;73(4):244-.
Menzes S and GB Malik, A study of leukemias in Goa. Indian J of Path and Micro. 1977;20:83-90.
Varghese PR, Elayidom NB, Joseph CD, Kumar S. Epidemiological observations on leukaemia in Kerala (A study of 1016 cases over three years). Ind J Haematol. 1984;2:15-7.
Cranfield T, Bunch C. Acute leukemias. Med Int. 1995;9:503-8.