Intravenous ibutilide versus intravenous amiodarone for post-operative management of atrial fibrillation following coronary artery bypass grafting: a prospective randomized controlled double blinded trial

Authors

  • Ankur Gandhi Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Aradhaya Verma Department of Anaesthesia, GBH Cancer Memorial Hospital, Udaipur, Rajasthan, India
  • Aditya Sharma Clinical Associate, Critical Care, Jaslok Hospital and Research Centre, Mumbai, India
  • Sanjay Gandhi Department of Cardiothoracic and Vascular Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Mohammed Abdul Salman Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Deependra Singh Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20215038

Keywords:

Post-operative atrial fibrillation, Amiodarone, Ibutilide, Coronary artery bypass grafting

Abstract

Background: Increased incidence of post-operative atrial fibrillation (POAF) is responsible for more post-operative complications, length of hospital stay and subsequent higher costs of hospitalization. This study was done to compare the efficacy and safety of ibutilide versus amiodarone for treatment of POAF following coronary artery bypass grafting (CABG).

Methods: In this prospective, randomized, double blind controlled study, 60 patients posted for CABG developing POAF, divided randomly into 30 patients each in groups A and group I. Group A received IV amiodarone at 3 mg/kg over 20 minutes and group I received IV ibutilide at 0.01 mg/kg over 10 minutes (weight <60 kg) or 1 mg over 10 minutes (weight >60 kg). Patients underwent standard anesthetic technique and monitoring for CABG. All the demographic data, hemodynamic data were recorded in a structured manner.

Results: Ibutilide showed significantly faster resolution of AF at 12.47±5.3 versus 22.9±7.68 minutes by amiodarone (p=0.000). Ibutilide was found to have significantly higher incidences of recurrence at 23.3% versus 0% by amiodarone (p=0.0048). Ibutilide showed significantly lesser hypotension 0% versus 26.67% with amiodarone (p=0.002).

Conclusions: This study concluded that ibutilide was found to be better suited to treat POAF patients, who underwent CABG; due to its early and efficient resolution and reduced risk of hypotension.

Author Biographies

Ankur Gandhi, Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

Associate Professor, Department of Anaesthesia

Aradhaya Verma, Department of Anaesthesia, GBH Cancer Memorial Hospital, Udaipur, Rajasthan, India

Senior Resident, Department of Anaesthesia

Aditya Sharma, Clinical Associate, Critical Care, Jaslok Hospital and Research Centre, Mumbai, India

Clinical Associate, Critical care

Sanjay Gandhi, Department of Cardiothoracic and Vascular Surgery, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

Associate Professor, Department of Cardiothoracic and Vascular Surgery

Mohammed Abdul Salman, Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

Final Year Resident, Department of Anaesthesia

Deependra Singh, Department of Anaesthesia, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

2nd Year Resident, Department of Anaesthesia

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Published

2021-12-28

How to Cite

Gandhi, A., Verma, A., Sharma, A., Gandhi, S., Salman, M. A., & Singh, D. (2021). Intravenous ibutilide versus intravenous amiodarone for post-operative management of atrial fibrillation following coronary artery bypass grafting: a prospective randomized controlled double blinded trial. International Journal of Research in Medical Sciences, 10(1), 98–104. https://doi.org/10.18203/2320-6012.ijrms20215038

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Original Research Articles