Observational study to characterize socio-demographic data and clinical presentation in patients with acute exacerbation of chronic obstructive pulmonary disease

Amit Sharma, Mamta Bhardwaj, Prerna Jain, Devika Tayal


Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease with high global morbidity and mortality. It is characterized by poorly reversible airway obstruction. The major risk factor associated is smoke exposure which leads to chronic respiratory failure. Various chronic medical conditions commonly coexisting with COPD include coronary artery disease, diabetes mellitus, osteoporosis and muscle weakness. Co-morbid conditions should be managed appropriately along with treatment of COPD. Present observational study was undertaken to characterize socio-demographic data, clinical presentation and possible co-morbidities (cardiac, diabetes mellitus, and hypertension) in COPD patients. The observed data was analyzed to study prevalence of all parameters gender wise and relation with diagnostic technique i.e. chest X-ray and electrocardiography (ECG) for cardiac screening. Therefore, in the following study, elderly and male patients were prominently affected by COPD with common symptoms of cough, breathlessness, expectoration, fever and chest pain. Diabetes is one of the co-morbidities observed in this set of patients. Hence, random blood sugar (RBS) and glycated hemoglobin (HbA1c) parameters were deranged in this cohort of patients. Additionally, ECG was also observed to be abnormal in few patients. Conclusively, this study highlighted various demographic features, clinical symptoms and comorbidities responsible for health burden of COPD patients.


Respiratory, Comorbidities, Acute exacerbation of chronic obstructive pulmonary disease

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Mathioudakis AG, Vanfleteren LE, Lahousse L, Higham A, Allinson JP, Gotera C, Visca D, Singh D, Spanevello A. Current developments and future directions in COPD. Eur Resp Rev. 2020;31:29(158).

Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Resp J. 2019;53(5).

Raherison C, Girodet PO. Epidemiology of COPD. Eur Resp Rev. 2009;18(114):213-21.

Blanco I, Diego I, Bueno P, Casas-Maldonado F, Miravitlles M. Geographic distribution of COPD prevalence in the world displayed by Geographic Information System maps. Eur Resp J. 2019;54(1).

Verma A, Gudi N, Yadav UN, Roy MP, Mahmood A, Nagaraja R, Nayak P. Prevalence of COPD among population above 30 years in India: A systematic review and meta-analysis. J Global Health. 2021;11.

Daniel RA, Aggarwal P, Kalaivani M, Gupta SK. Prevalence of chronic obstructive pulmonary disease in India: A systematic review and meta-analysis. Lung India: Official Organ of Indian Chest Society. 2021;38(6):506.

Chatila WM, Thomashow BM, Minai OA, Criner GJ, Make BJ. Comorbidities in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2008;5(4):549-55.

Lai CC, Wu CH, Wang YH, Wang CY, Wu VC, Chen L. The association between COPD and outcomes of patients with advanced chronic kidney disease. Int J Chronic Obstructive Pulmonary Dis. 2018;13:2899.

Viglino D, Jullian-Desayes I, Minoves M, Aron-Wisnewsky J, Leroy V, Zarski JP, Tamisier R, Joyeux-Faure M, Pepin JL. Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease. Eur Resp J. 2017;49(6).

Chetty U, McLean G, Morrison D, Agur K, Guthrie B, Mercer SW. Chronic obstructive pulmonary disease and comorbidities: a large cross-sectional study in primary care. Br J Gen Pract. 2017;67(658):321-8.

Castelino F, Prabhu M, Pai MS, Kamath A, Mohapatra AK, Devi ES, George A, Nayak SG. Socio-demographic and clinical characteristics of Chronic Obstructive Pulmonary Disease (COPD) patients. Manipal Journal of Nursing and Health Sciences (MJNHS). 2017;3(2):55-8.

Miravitlles M, Ribera A. Understanding the impact of symptoms on the burden of COPD. Resp Res. 2017;18(1):1.

Kent BD, Mitchell PD, McNicholas WT. Hypoxemia in patients with COPD: cause, effects, and disease progression. Int J Chronic Obstructive Pulmonary Dis. 2011;6:199.

Horiuchi M, Kirihara Y, Fukuoka Y, Pontzer H. Sex differences in respiratory and circulatory cost during hypoxic walking: potential impact on oxygen saturation. Sci Rep. 2019;9(1):1-0.

Richards JC, McKenzie DC, Warburton DE, Sheel AW. Prevalence of exercise-induced arterial hypoxemia in healthy women. Med Sci Sports Exercise. 2004;36(9):1514-21.

Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPD Gene study. Resp Med. 2011;105(8):1211-21.

Warnier MJ, Rutten FH, Numans ME, Kors JA, Tan HL, de Boer A, Hoes AW, De Bruin ML. Electrocardiographic characteristics of patients with chronic obstructive pulmonary disease. J Chronic Obstructive Pulmonary Dis. 2013;10(1):62-71.

Mohamed EE, Abd Allah AE. The efficacy of diabetes control on the outcome, duration of ICU stay, and the need for mechanical ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberculosis. 2019;68(2):175.