Clobetasol propionate 0.025%: a topical therapeutic for skin diseases


  • Jatinder K. Sadana Department of Dermatology, Dr. Sadanas Skin Clinic and Laser Centre, Patiala, Punjab, India
  • Anshuman Rai Department of Dermatology, Skin and Dental Care, Azamgarh, Uttar Pradesh, India
  • Meenu Sethi Department of Dermatology, Skyn Stories, Gurugram, Haryana, India
  • Deepshikha Khanna Department of Dermatology, Upasana ENT, Skin and Laser Clinic, Patparganj, Delhi, India
  • Suresh K. Jain Department of Dermatology, Jain Clinic, Kota, Rajasthan, India
  • Rakesh Bharti Department of Dermatology, Bharti Derma Care and Research Center, Amritsar, Punjab, India
  • Salman S. Bhoira Department of Dermatology, Skin and Hair Clinic, Bandra, Mumbai, India
  • Ashish Dhamija Department of Dermatology, Dhamija Skin Care and Laser Clinic, Bahadurgarh, Delhi, India
  • Kiran V. Nabar Department of Dermatology, Pooja Clinic, Alibaug, Mumbai, India
  • Naresh K. Banjara Department of Dermatology, Skin Clinic, Sawai Madhopur, Rajasthan, India



Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids


The most widely recommended drugs for the treatment of a variety of dermatoses are topical corticosteroids (TC). These medications are approved for the treatment of inflammatory and pruritic manifestations of dermatologic disorders due to their powerful, symptom-relieving impact. Clobetasol propionate (CP) is the most popular TC used to relieve itching, redness, and edema caused by skin disorders. Topical corticosteroids exhibit anti-inflammatory, anti-pruritic, and vasoconstrictive activities. Clobetasol propionate binds to cytoplasmic glucocorticoid receptors and activates glucocorticoid receptor-mediated gene expression, resulting in the production of anti-inflammatory proteins and suppression of the production of inflammatory mediators. The effectiveness, safety, and clinical experience of utilizing CP 0.025% topical therapy for the treatment of various dermatologic disorders are discussed in this case series.


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How to Cite

Sadana, J. K., Rai, A., Sethi, M., Khanna, D., Jain, S. K., Bharti, R., Bhoira, S. S., Dhamija, A., Nabar, K. V., & Banjara, N. K. (2022). Clobetasol propionate 0.025%: a topical therapeutic for skin diseases. International Journal of Research in Medical Sciences, 10(6), 1354–1360.



Case Series