Clobetasol propionate 0.025%: a topical therapeutic for skin diseases

Jatinder K. Sadana, Anshuman Rai, Meenu Sethi, Deepshikha Khanna, Suresh K. Jain, Rakesh Bharti, Salman S. Bhoira, Ashish Dhamija, Kiran V. Nabar, Naresh K. Banjara


The most widely recommended drugs for the treatment of a variety of dermatoses are topical corticosteroids (TC). These medications are approved for the treatment of inflammatory and pruritic manifestations of dermatologic disorders due to their powerful, symptom-relieving impact. Clobetasol propionate (CP) is the most popular TC used to relieve itching, redness, and edema caused by skin disorders. Topical corticosteroids exhibit anti-inflammatory, anti-pruritic, and vasoconstrictive activities. Clobetasol propionate binds to cytoplasmic glucocorticoid receptors and activates glucocorticoid receptor-mediated gene expression, resulting in the production of anti-inflammatory proteins and suppression of the production of inflammatory mediators. The effectiveness, safety, and clinical experience of utilizing CP 0.025% topical therapy for the treatment of various dermatologic disorders are discussed in this case series.


Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids

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