DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20221586

Clinical profile and histo-pathological profile of peri-ocular lesions

Bhavani Raina, Sachit Mahajan, Sanjay Kai

Abstract


Background: Eyelid carcinoma is the most common malignant lesion of eyelid region, and may involve either skin or tarus or inner layer of eyelid. The most common primary eyelid malignancy is basal cell carcinoma (BCC), squamous cell carcinoma (SqCC), sebaceous gland carcinoma (SGC), malignant melanoma, and Merkel cell carcinoma. The prevalence of these malignant lesion vary according to the geographical region. The aim of the study was to correlate the diagnosis of various peri-ocular lesions with the histological diagnosis.

Methods: This prospective longitudinal study was conducted over a period of two years in patients with ocular and periocular skin lesions. All the patients underwent incision biopsy of the lesion biopsy material was sent for histopathology examination. The histological profile of the tumour was confirmed by the report.

Results: The mean age in our study was 32.7±18.4 years with age range of 18 to 78 years, with 108 females (54%) and 92 males (46%). 173 (86.5%) were benign lesions and 27 (13.5%) were malignant lesions. Right eye was involved in more cases (n=104, 52%) as compared to left eye (n=96, 48%). Upper eye lid was involved more (n=102, 51%) than lower eye lid (n=98, 49%). Epidermal cyst was most common lesion (n=43, 21.5%), followed by dermoid cyst (n=28, 14%). Sebaceous gland carcinoma was most (n=15, 7.5%) malignant lesion, followed by basal cell carcinoma (n=7, 3, 5%).

Conclusions: All excised eyelid lesions must be submitted for histopathologic confirmation to achieve 100% accuracy in diagnosis and treatment. Early diagnosis remains essential for adequate functional and cosmetic lid reconstruction.


Keywords


Eyelid tumours, Histopathology, Malignancy, Cyst

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References


Pe'er J. Pathology of eyelid tumors. Indian J Ophthalmol. 2016;64(3):177-90.

Faky YH. Epidemiology of benign eyelid lesions in patients presenting to a teaching hospital. Saudi J Ophthalmol. 2012;26(2):211-6.

Esmaeli B, Dutton J, Graue GF. Eyelid carcinoma. AJCC Cancer Staging Manual. 8th ed. Germany: Springer; 2017.

Huang YY, Liang WY, Tsai CC, Kao SC, Yu WK, Kau HC, et al. Comparison of the Clinical Characteristics and Outcome of Benign and Malignant Eyelid Tumors: An Analysis of 4521 Eyelid Tumors in a Tertiary Medical Center. Biomed Res Int. 2015;2015:453091.

Font RL, Croxatto JO, Rao NA. Tumors of the eyelids. Tumors of the Eye and Ocular Adnexa. Washington, USA: American Registry of Pathology; 2006.

Watanabe A, Sun MT, Pirbhai A, Ueda K, Katori N, Selva D. Sebaceous carcinoma in Japanese patients: clinical presentation, staging and outcomes. Br J Ophthalmol. 2013;97(11):1459-63.

Kersten RC, Ewing-Chow D, Kulwin DR, Gallon M. Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology. 1997;104(3):479-84.

Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009;31(3):256-62.

Jahagirdar SS, Thakre TP, Kale SM, Kulkarni H, Mamtani M. A clinicopathological study of eyelid malignancies from central India. Indian J Ophthalmol. 2007;55(2):109-12.

Jangir MK, Kochar A, Khan NA, Jaju M. Profile of eyelid tumours: histopathological examination and relative frequency at A tertiary centre in north–west Rajasthan. Delhi J Ophthalmol. 2017;28:30-5.

Rathod A, Pandharpurkar M, Toopalli K, Bele S. A clinicopathological study of eyelid tumours and its management at a tertiary eye care centre of Southern India. MRIMS J Health Sci. 2015;3(1):54-8.

Cook BE, Bartley GB. Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota. Ophthalmology. 1999;106(4):746-50.

Krishnamurthy H, Tanushree V, Venkategowda HT, Archana S, Mobin G, Aylette D, et al. Profile of eyelid tumours at tertiary care institute in karnataka: a 5-years survey. JEMDS. 2014;3(50):11818-32.

Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F, Jonas JB. Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging. 2008;39(5):367-72.

Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009;31(3):256-62.

Paul S, Dat T, Rona Z. Malignant and Benign Eyelid Lesions in San Franscisco: Study of a Diverse Urban Population. American J Clin Med. 2011;8(1):40-6.

Obata H, Aoki Y, Kubota S, Kanai N, Tsuru T. Incidence of benign and malignant lesions of eyelid and conjunctival tumors. Nippon Ganka Gakkai Zasshi. 2005;109(9):573-9.

Sihota R, Tandon K, Betharia SM, Arora R. Malignant eyelid tumors in an Indian population. Arch Ophthalmol. 1996;114(1):108-9.

Abdi U, Tyagi N, Maheshwari V, Gogi R, Tyagi SP. Tumours of eyelid: a clinicopathologic study. J Indian Med Assoc. 1996;94(11):405-9.

Wang CJ, Zhang HN, Wu H, Shi X, Xie JJ, He JJ, et al. Clinicopathologic features and prognostic factors of malignant eyelid tumors. Int J Ophthalmol. 2013;6(4):442-7.

Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F, et al. Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging. 2008;39(5):367-72.

Chi MJ, Baek SH. Clinical analysis of benign eyelid and conjunctival tumors. Ophthalmologica. 2006;220(1):43-51.