Published: 2022-07-27

A challenging case of fenofibrate induced neutropenia

Bindumathi Pula Lakshmi, Spandana Peddareddy, N. Aditya Murali, Swati Rajagopal


Fenofibrate induced neutropenia is a rare condition. We reported 59-year-old male who developed neutropenia after taking fenofibrate for 20 days. He presented with complaints of fever, upper respiratory tract infection (URTI) symptoms. At presentation his total counts were 800. He was evaluated thoroughly for other causes of neutropenia and was treated with antibiotics, steroids, G-CSF. Once the fenofibrate was stopped, patient counts improved and his symptoms subsided. Hence, it is very important to always keep in mind the possibility of side effects of drugs, however remotely rare they are. 


Neutropenia, Absolute neutrophil count, Drug-induced, Fenofibrate, Filgrastim

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Boxer LA. How to approach neutropenia. Hematology Am Soc Hematol Educ Program. 2012;1:174-82.

Gibson C, Berliner N. How we evaluate and treat neutropenia in adults. Blood. 2014;124(8):1251-8.

Bhatt V, Saleem A. Drug-induced neutropenia-Pathophysiology, Clinical features, and management. Ann Clin Lab Sci. 2004;34(2):131-7.

Palmblad J, Dufor C, Papdaki HA. How we diagnose neutropenia in the adult and elderly patient. Haematologica. 2014;99(7):1130-3.

Kacirova I, Grudmann M. Fenofibrate-induced anemia and neutropenia-A case report. J Clinthera. 2015;37(8):E103.

Sidhu G, Tripp J. Fenofibrate. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2022.

Capsoni F, Sarzi-Puttini A, Zanella A. Primary and secondary autoimmune neutropenia. Arthritis Res Ther. 2005;7(5):208-14.

Dale DC. Advances in the treatment of neutropenia. Curr Opin Support Palliat Care. 2009;3(3):207-12.

Akamizu T, Ozaki S, Hiratani H. Drug-induced neutropenia associated with anti-neutrophilic cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity. Clin Exp Immunol. 2002;127:92-8.

Symeonidis A, Kouraklis-Syemeonidis A, Seimeni U. Ticlopidine-Induced aplastic anemia: two new case reports, reviews, and meta-analysis of 55 additional cases. Am J Haematol. 2002;71:24-32.