Factors related to the death of diabetic patients with COVID-19 hospitalized in Joseph Raseta Befelatanana University Hospital in Antananarivo, Madagascar

Authors

  • Miora M. A. Andrianiaina Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar
  • Tsikinirina V. Randrianomanana Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar
  • Rija E. Raherison Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar
  • Thierry Razanamparany Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar
  • Sitraka A. Raharinavalona Department of Internal Medicine and Cardiovascular Diseases, Soavinandriana Hospital, Antananarivo Madagascar
  • Jean F. Rafamatanantsoa Public Health Care University Hospital Center, Analakely, Antananarivo, Madagascar
  • Andrianirina D. P. Rakotomalala Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar
  • Radonirina L. Andrianasolo Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar

DOI:

https://doi.org/10.18203/2320-6012.ijrms20222256

Keywords:

COVID-19, Death, Diabetes mellitus, Risk factors

Abstract

Background: Diabetes mellitus is associated with severe and even fatal forms of COVID-19. The objective of this study was to identify the factors linked to the death of COVID-19 diabetic patients in order to improve their care.

Methods: An analytical cross-sectional study was carried out in the endocrinology department of the Joseph Raseta Befelatanana University Hospital Center, Antananarivo, Madagascar. It has concerned all the cases of COVID-19 diabetics (162 patients) recorded from April 2020 to July 2021 (16 months).

Results: In our study, the case fatality rate of COVID-19 in diabetics was 14.49%. Significant factors related to death, after univariate analysis, were:  vascular complications including nephropathy (OR=4.74), neuropathy  (OR=5.38) and ischemic heart disease (OR=3.9), presence of other comorbidities (OR=9.02), dyspnea (OR=4.60), seizures (OR=6.22) or alertness disorder (OR=4.35), lower oxygen saturation (p=0.04), pleurisy (OR=4.67), signs of cardiac decompensation (OR=3.46), an elevated mean blood sugar level (p<0.001), leukocytosis (p=0.02) and thrombocytopenia (p<0.001), impaired renal function (p=0.02) and pleurisy on chest imaging (OR=5.29).

Conclusions: Death factors in diabetics with COVID-19 can be diverse. They do not only include the cardiovascular complications of the diabetes, but also a worse clinical respiratory presentation on the admission, a higher inflammatory syndrome, and a greater imbalance of blood sugar during the hospitalization.

 

Author Biography

Miora M. A. Andrianiaina, Department of Endocrinology, Joseph Raseta Befelatanana University Hospital (CHUJRB), Antananarivo, Madagascar

Faculty of Medicine

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Published

2022-08-29

How to Cite

Andrianiaina, M. M. A., Randrianomanana, T. V., Raherison, R. E., Razanamparany, T., Raharinavalona, S. A., Rafamatanantsoa, J. F., Rakotomalala, A. D. P., & Andrianasolo, R. L. (2022). Factors related to the death of diabetic patients with COVID-19 hospitalized in Joseph Raseta Befelatanana University Hospital in Antananarivo, Madagascar. International Journal of Research in Medical Sciences, 10(9), 1839–1847. https://doi.org/10.18203/2320-6012.ijrms20222256

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Original Research Articles