Obesity and glycated hemoglobin: is there a relation with oxygen saturation in type 2 diabetes mellitus?

Authors

  • Nusrat Chouhan Department of Physiology, GMC, Jammu, Jammu and Kashmir, India
  • Monica Manhas Department of Physiology, GMC, Jammu, Jammu and Kashmir, India
  • Suman Kotwal Department of Endocrinology, SSH, GMC, Jammu, Jammu and Kashmir, India
  • Mohsina Majid Department of Physiology, GMC, Jammu, Jammu and Kashmir, India
  • Mrityunjay . Department of Physiology, GMC, Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20222081

Keywords:

HbA1c, Oxygen saturation, Obesity, T2DM

Abstract

Background: Diabetics and obese persons are highly susceptible to cardiovascular diseases (CVD). Obesity causes hypoxemia and glycated hemoglobin (HbA1c) also is known to lower the oxygen-carrying capacity and related systemic vascular vasodilatory adaptations and responses. Aim was to assess the effect of obesity and glycosylated hemoglobin on oxygen saturation in patients of type 2 diabetes mellitus (T2DM).

Methods: HbA1c level and oxygen saturation (SpO2) were measured in 100 adult, obese (Body mass index>30) T2DM patients.

Results: Mean HbA1C and SpO2 values were 8.69±2.41% and 95.24±3.23% respectively. P value for correlation between SpO2 and BMI was 0.3. On the other hand, p-value for correlation between SpO2 and HbA1c was 0.679

Conclusions: There was no significant effect of obesity and HbA1c on oxygen saturation in T2DM patients.

Author Biographies

Nusrat Chouhan, Department of Physiology, GMC, Jammu, Jammu and Kashmir, India

Department of Physiology, Demonstrator

Monica Manhas, Department of Physiology, GMC, Jammu, Jammu and Kashmir, India

Department of Physiology, Asistant Professor

Suman Kotwal, Department of Endocrinology, SSH, GMC, Jammu, Jammu and Kashmir, India

Department of Endocrinology, Assistnt Professor

Mohsina Majid, Department of Physiology, GMC, Jammu, Jammu and Kashmir, India

Department of Physiology, Junior Resident

Mrityunjay ., Department of Physiology, GMC, Jammu, Jammu and Kashmir, India

Department of Physiology, Professor

References

Pi-Sunyer X. CV-behnaz Toluei. Postgr Med. 2010;121(6):21-33.

Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635-43.

Nuttall FQ. Body mass index: obesity, BMI, and health: a critical review. Nutrition today. 2015;50(3):117.

Littleton SW, Tulaimat A. The effects of obesity on lung volumes and oxygenation. Respir Med. 2017;124:15-20.

Kabon B, Nagele A, Reddy D, Eagon C, Fleshman JW, Sessler DI, Kurz A. Obesity decreases perioperative tissue oxygenation. J Am Society Anesthesiologists. 2004;100(2):274-80.

Garg S, Gupta S, Mobeen S, Venkata S. Diabetes & Metabolic Syndrome: Clinical Research & Reviews Effect of obesity and glycated hemoglobin on oxygen saturation in ambulatory type 2 diabetic individuals: A pilot study. Diabetes Metab Syndr Clin Res Rev. 2016;10-3.

Shanthi B, Revathy C, Devi AJ. Effect of iron deficiency on glycation of haemoglobin in nondiabetics. Journal of clinical and diagnostic research: JCDR. 2013;7(1):15.

Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomark Insights. 2016;11:95-104.

Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137-88.

Diabetes DOF. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2007;30(1).

Levy BI, Schiffrin EL, Mourad J, Agostini D, Vicaut E, Safar ME et al. Impaired Tissue Perfusion A Pathology Common to Hypertension, Obesity and Diabetes Mellitus. Diabetes Care. 2008;968-76.

Bertoni AG, Saydah S, Brancati FL. Diabetes and the risk of infection-related mortality in the US. Diabetes Care. 2001;24(6):1044-9.

Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obesity. 2013;37(3):333-40.

Falagas ME, Kompoti M. Obesity and infection. Lancet infectious diseases. 2006;6(7):438-46.

Cifarelli V, Beeman SC, Smith GI, Yoshino J, Morozov D, Beals JW et al. Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity. J Clin Investigation. 2020;130(12):6688-99.

Catrina SB, Zheng X. Hypoxia and hypoxia-inducible factors in diabetes and its complications. Diabetologia. 2021;64(4):709-16.

Ye S, Ruan P, Yong J. The impact of the HbA1c level of type 2 diabetics on the structure of haemoglobin. Sci Rep. 2016;6:33352.

Zavorsky GS, Murias JM, Kim DJ, Gow J, Sylvestre JL, Christou N V. Waist-to-hip ratio is associated with pulmonary gas exhange in the morbidly obese. Chest. 2007;131(2):362-7.

Pu LJ, Shen Y, Lu L, Zhang RY, Zhang Q, Shen WF. Increased blood glycohemoglobin A1c levels lead to overestimation of arterial oxygen saturation by pulse oximetry in patients with type 2 diabetes. Cardiovasc Diabetol. 2012;11:110.

Hammad M A, Syed Sulaiman S A, Aziz N A, Elsayed T M, Mohamed Noor D A. PSY7-Impact of obesity on glycated hemoglobin control among patients with type 2 diabetes mellitus. Value in Health. 2018;21:S436-7.

Fawzi H, Hussein AM, Ahmed HJ, Mitham ZS. Study of Glycated Hemoglobin (Hba1c) in Obese Diabetics Patients and Non-Obese Diabetics Patients. Int J Med Res Prof. 2016;2(1):61-4.

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Published

2022-08-29

How to Cite

Chouhan, N., Manhas, M., Kotwal, S., Majid, M., & ., M. (2022). Obesity and glycated hemoglobin: is there a relation with oxygen saturation in type 2 diabetes mellitus?. International Journal of Research in Medical Sciences, 10(9), 1904–1907. https://doi.org/10.18203/2320-6012.ijrms20222081

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Original Research Articles