Extensiveness and homogeneity of diabetic/non-diabetic patients and their co-relation with CBNAAT confirmed tuberculosis patients in a tertiary care hospital of India
DOI:
https://doi.org/10.18203/2320-6012.ijrms20222851Keywords:
CBNAAT, Diabetes mellitus, Diabetic/non-diabetic, GeneXpert, Pulmonary impairment, TuberculosisAbstract
Background: Many studies reported association between TB susceptibility and diabetes mellitus (DM). Some studies were retrospective, did not assess other co morbidities related with tuberculosis. The effects of diabetes on tuberculosis severity (EDOTS) can be hypothesizing that burden of cases India is leading in TB and runner-up in diabetic. We report interim findings after enrolling 732 of a planned 212 subjects.
Methods: This study conducted on patients with TB in west India with DM and normoglycemia defined by glucose tolerance test (GTT) and glucose fasting. Glycocylated hemoglobin (HbA1c), lipids profile and 25-hydroxyvitamin D were measured at the time of enrollment of patients. All patients were monitored monthly while they visited in TB and chest clinic for TB treatment.
Results: Of 212 eligible patients, 117 (55.18%) were classified as diabetic, 49 (23.11%) with pre diabetic history (PDM), and 46 (21.70%) as normoglycemic (NG). DM patients were more likely to have a family history of diabetes in comparison to NG patients. Low density lipoprotein (LDH)) was higher in KDM as compared with NDM and NG patients. More patients (32) found diabetic through OGTT as compared with HbA1c (29).
Conclusions: Early EDOTS, glycemic control and improve lifestyle can reduce the heterogeneity and implications for the TB-DM. Early diagnosis of TB and DM plays an important role in the management and treatment of TBDM.
References
Nagar V, Prasad P, Gour D, Singh AR, Pal DK. Screening for diabetes among tuberculosis patients registered under revised national tuberculosis control program, Bhopal, India. J Fam Med Prim Care. 2018;7(6):1401-5.
Koch A, Mizrahi V. Mycobacterium tuberculosis. Trends Microbiol. 2018;26(6):555-6.
Tuberculosis key facts. World Health Organization. 2020. Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis. Accessed on 2 December 2021.
Basic TB Facts. Centers for Disease Control and Prevention. Tuberculosis. 2020. Available from: https://www.cdc.gov/tb/topic/basics/default. Accessed on 2 December 2021.
Prakash BC, Ravish KS, Prabhakar B, Ranganath TS, Naik B, Satyanarayana S, et al. Tuberculosis-diabetes mellitus bidirectional screening at a tertiary care centre, South India. Public Health Action. 2013;3(1):18-22.
Mave V, Nimkar S, Prasad H, Kadam D, Meshram S, Lokhande R, et al. Tuberculosis screening among persons with diabetes mellitus in Pune, India. BMC Infect Dis. 2017;17(1):388.
Zaman K. Tuberculosis: a global health problem. J Health Popu Nutr. 2010;28(2):111-3.
World Health Organization 2021. Available at: https://www.who.int/news-room/fact-sheets/detail/tuberculosis. Accessed on 14 October 2021.
Islam SM, Purnat TD, Phuong NT, Mwingira U, Schacht K, and Fröschl G. Non-communicable diseases (NCDs) in developing countries: a symposium report. Globaliz Health. 2014;10(81):12992.
NCD Countdown 2030 collaborators. NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.4. Lancet. 2018;392(10152):1072-88.
World Health Organization. Global Tuberculosis Report. Geneva; 2013. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports. Accessed on 2 December 2021.
Pizzol D, Veronese N, Marotta C, Gennaro DF, Moiane J, Chhaganlal K, et al. Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique. BMC Res Notes. 2018;11(99):13104.
Pande T, Huddart S, Xavier W, Kulavalli S, Chen T, Pai M, et al. Prevalence of diabetes mellitus amongst hospitalized tuberculosis patients at an Indian tertiary care center: a descriptive analysis. Plos One. 2018;13(7):0200838.
Naik B, Kumar AM, Satyanarayana S, Suryakant MD, Swamy NM, Nair S, et al. Is screening for diabetes among tuberculosis patients feasible at the field level? Public Health Action. 2013;3(Suppl 1):S34-7.
Majumdar A, Wilkinson E, Rinu PK, Maung TM, Bachani D, Punia JS, et al. Tuberculosis-diabetes screening: how well are we doing? A mixed-methods study from North India. Public Health Act. 2019;9(1):3-10.
Gaur V, Singh AK, Kumar A, Mishra AK. Utility and effectiveness of genexpert over conventional methods for diagnosis of pulmonary tuberculosis. Int J Pharm Sci Res. 2020;11(9):4629-36.
Workneh MH, Bjune GA, Yimer SA. Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review. PloS One. 2017;12(4):0175925.
Thapa B, Paudel R, Thapa P, Shrestha A, Poudyal. Prevalence of diabetes among tuberculosis patients and associated risk factors in Kathmandu Valley. SAARC J Tubercul Lung Dis HIV/AIDS. 2016;12(2):20-7.
Haraldsdottir TL, Rudolf F, Bjerregaard MA, Joaquím LC, Stochholm K, Gomes VF, et al. Diabetes mellitus prevalence in tuberculosis patients and the background population in Guinea-Bissau: a disease burden study from the capital Bissau. Transact Royal Soc Trop Med Hyg. 2015;109(6):400-7.
Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lönnroth K, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9(81):7015.
Damtew E, Ali I, Meressa D. Prevalence of diabetes mellitus among active pulmonary tuberculosis patients at St. Peter Specialized hospital, Addis Ababa, Ethiopia. World J Med Sci. 2014;11(3):389-96.
Rajaa S, Krishnamoorthy Y, Knudsen S, Roy G, Ellner J, Horsburgh CR, et al. Prevalence and factors associated with diabetes mellitus among tuberculosis patients in South India-a cross-sectional analytical study. BMJ Open. 2021;11(10):050542.
Viswanathan V, Kumpatla S, Aravindalochanan V, Rajan R, Chinnasamy C, Srinivasan R, et al. Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India. PloS One. 2012;7(7):41367.
Raghuraman S, Vasudevan KP, Govindarajan, S, Chinnakali P, Panigrahi KC. Prevalence of diabetes mellitus among tuberculosis patients in urban Puducherry. North Am J Med. Sci. 2014;6(1):30-4.
Mi F, Jiang G, Du J, Li L, Yue W, Harries AD, et al. Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China. Glob Health Act. 2014;19(7):24022.
Lin YH, Chen CP, Chen PY, Huang JC, Ho C, Weng HH, et al. Screening for pulmonary tuberculosis in type 2 diabetes elderly: a cross-sectional study in a community hospital. BMC Public Health. 2015;15(3):2458.
Thapa B, Paudel R, Thapa P, Shrestha A, Poudyal AK. Prevalence of diabetes among tuberculosis patients and associated risk factors in Kathmandu valley. SAARC J Tubercul Lung Dis HIV/AIDS. 2015;12(2):20-7.
Pavlovic JM, Pavlovic AD, Bulajic MV, Pesut DP. Prevalence of diabetes mellitus (DM) in tuberculosis (TB) patients: clinical and radiologic features in the TB-DM association based on a five-year hospital study. Le Infez Med. 2018;26(1):22-7.
Aftab H, Christensen DL, Ambreen A, Jamil M, Garred P, Petersen JH, et al. Tuberculosis-related diabetes: is it reversible after complete treatment. Am J Trop Med Hyg. 2017;97(4):1099-102.
Alisjahbana B, Sahiratmadja E, Nelwan JE, Purwa MA, Ahmad Y, Ottenhoff HMT, et al. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis. 2007;45(4):428-35.
Dooley KE, Tang T, Golub JE, Dorman SE, Cronin W. Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis. Am J Trop Med Hyg. 2009;80(4):634-9.
Dousa KM, Hamad A, Albirair M, Al Soub H, Elzouki AN, Alwakeel MI, et al. Impact of diabetes mellitus on the presentation and response to treatment of adults with pulmonary tuberculosis in Qatar. Open Forum Infect Dis. 2018;6(1):335.
