Immunohistochemical expression of galectin-3 in carcinoma of uterine cervix

Authors

  • Chandershekhar . Department of Pathology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
  • Gajender Singh Department of Pathology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
  • Monika Dhankher Department of Pathology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
  • Zeany Cheran Department of Pathology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20222871

Keywords:

IHC, Galectin 3, Tumor grade

Abstract

Background: Cervical cancer is one of the most common cancer among women worldwide, second to breast cancer. It’s difficult to diagnose in the early stage due to subtle and non-specific symptoms. Galectin-3 is increasingly being recognized as an important regulator of a broad range of cancer cell activities including cervical cancer. Its expression depends on the tumor grade which signifies its role in progression of the disease and prognostic significance.

Method: The present study was conducted in department of pathology, Pt. B. D. Sharma PGIMS, Rohtak on 60 cases of histo-pathologically diagnosed squamous cell carcinoma of uterine cervix. Immunohistochemical (ICH) expression of marker ‘Galectin-3’was assessed in all biopsy specimens.

Results: Galectin-3 expression was 1+ in 83.3% cases and 2+ in 16.6% cases of grade 1 cervix carcinoma. In grade 2 carcinomas 55.3% showed 1+, 42.1% showed 2+ and 2.6 % cases showed 0 galectin -3 expression. Further, 70% of grade III cases showed a score of 2+, and 10 % showed 1+ expression and 20 % didn’t show any galectin 3 positivity. A statistically significant association of galectin-3 expression with histological grade was observed.

Conclusions: IHC expression of galectin-3 can be used as an important marker for grading of cervical carcinoma, therefore the present study was done to evaluate the IHC expression of galectin 3 in cervical cancer and correlate it with histologic tumour grade.

References

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Published

2022-10-28

How to Cite

., C., Singh, G., Dhankher, M., & Cheran, Z. (2022). Immunohistochemical expression of galectin-3 in carcinoma of uterine cervix. International Journal of Research in Medical Sciences, 10(11), 2628–2632. https://doi.org/10.18203/2320-6012.ijrms20222871

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Original Research Articles