Published: 2022-11-25

Cystic nephroma in a 14-year-old-a rare case report

Reshmi Gopal, Niveditha Ezhilarasan Nila, Dhanya Menon, Vimal Chander C.


Cystic nephroma (CN) is an uncommon benign renal tumor with a bimodal age distribution. It often presents with non-specific presenting symptoms. In this study, we report a case of a 14-year-old female patient who presented with a painless abdominal mass, and a left renal cystic lesion was detected on CECT KUB. Left partial nephrectomy was done and a diagnosis of CN made following the histopathological examination of specimen. Owing to its non-specific clinical presentation and radiological findings, it is difficult to distinguish CN from other cystic lesions of kidney like cystic partially differentiated nephroblastoma, tubule-cystic renal cell carcinoma, cystic Wilm’s tumor etc., pre-op. This study emphasizes importance of histopathological examination in diagnosis of CN to prevent misdiagnosis and overtreatment. Although it has good prognosis, long term follow-up for local recurrence is recommended.


CN, Renal tumour, Case report, Histopathology

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Edmunds W. Cystic adenoma of kidney. Trans Pathol Soc. 1892;43:89-90.

Mukhopadhyay S, Valente AL, De la Roza G. Cystic nephroma: a histologic and immunohistochemical study of 10 cases. Arch Pathol Lab Med. 2004;128(12):1404-11.

Cajaiba MM, Khanna G, Smith EA, Gellert L, Chi YY, Mullen EA et al. Pediatric cystic nephromas: distinctive features and frequent DICER1 mutations. Human Pathol. 2016;48:81-7.

Huang SH, Chen TJ. Cystic nephroma of childhood: a case report and review of the literature. Urolog Sci. 2016;27(3):171-3.

Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Europ Urol. 2016;70(1):93-105.

A1 Bahubeshi, Bal N, Rio Frio T, Hamel N, Pouchet C, Yilmaz A et al. Germline DICER1 mutations and familial cystic nephroma. J Med Genet. 2010;47:863e6.

Granja MF, O'Brien AT, Trujillo S, Mancera J, Aguirre DA. Multilocular cystic nephroma: a systematic literature review of the radiologic and clinical findings. Am J Roentgenol. 2015;205(6):1188-93.

Eble JN, Bonsib SM. Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. In Seminars in Diagnostic Pathology. 1998;15(1):2-20.

Joshi VJ, Beckwith B. Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma. Cancer. 1989;64:466-79.

Li Y, Pawel BR, Hill DA, Epstein JI, Argani P. Pediatric cystic nephroma are morphologically, immunohistochemically, and genetically distinct from adult cystic nephroma. Am J Surgical Pathol. 2017;41(4):472.

González-Serrano A, Cortez-Betancourt R, Alías-Melgar A, Botello-Gómez PJ, Ramírez-Garduño E, Trujillo-Vázquez EI et al. Multilocular Cystic Renal Cell Carcinoma or Cystic Nephroma? Case Rep Urol. 2016;2016.

Moch H. Cystic renal tumors: new entities and novel concepts. Advances in anatomic pathology. 2010;17(3):209-14.

Boybeyi Ö, Karnak İ, Orhan D, Ciftci AO, Tanyel FC, Kale G et al. Cystic nephroma and localized renal cystic disease in children: diagnostic clues and management. J Pediatr Surg. 2008;43(11):1985-9.