Thyrotoxic periodic paralysis: a short clinical review

Rashmi Aggarwal, Pradeep Chugh


Thyrotoxic Periodic Paralysis (TPP) is a potentially lethal manifestation of hyperthyroidism which is characterized by hypokalemia and muscular weakness. It mainly affects Asian men in the age group of 20 to 40 years. Immediate supplementation with oral or intravenous potassium will help to not only abort the acute attack of paralysis but will also prevent serious and life threatening cardiac arrhythmias. Non selective beta blockers like propranolol can also be used to ameliorate and prevent subsequent paralytic attack. Acetazolamide has no role in the treatment of TPP.


Thyrotoxic periodic paralysis (TPP), Hypokalemia, Potassium, Propranolol

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