Acute T-cell lymphoblastic leukaemia presenting with cutaneous involvement in a child: a rare case report


  • Lohit Kumar Kalita Department of Oncology, Gauhati Medical College & Hospital, Guwahati, Assam
  • Chayanika Kalita Department of Dermatology, Gauhati Medical College & Hospital, Guwahati, Assam
  • Pabitra Kumar Gogoi Department of Clinical Hematology, Gauhati Medical College & Hospital, Guwahati, Assam
  • Umesh Chandra Sharma Vice-Chancellor, Srimanta Sankadeva University of Health Sciences, Narakasur HillTop, Guwahati, Assam


Acute lymphoblastic leukemia, Chest, Cutaneous, T-cell, Skin nodules


Primary cutaneous involvement in T-cell lymphoblastic leukemia is rare in childhood. We present a case of 6-year-old girl admitted to our hospital because of multiple skin lesions. She was looked pale and weak. Generalized lymphadenopathy was present. Complete blood count revealed 216,000/mm3 white blood cell count. Peripheral blood smear showed 80% lymphoblasts. Bone marrow aspiration revealed 96% blastic cells with immunophenotype and morphological characteristics of acute lymphoblastic leukemia (T-ALL) which was confirmed by flowcytometry.   ALL BFM -95 remission induction treatment protocol was started. Skin lesion remained same after two month of the cytotoxic therapy. The symptoms became more aggressive and she died after 4 months of treatment.


Boggs DR, Wintobe MM, Cartwright GE. The acute leukemias: analysis of 322 cases and review of the literature. Medicine. 1962;41:163-225.

Dunn NL, McWilliams NB, Mohanakumar T. Clinical and immunological correlates of leukemia cutis in childhood. Cancer. 1982;50:2049-51.

Millot F, Robert A, Bertrant Y, Mechinaud F, Laureys G, Ferster A, et al. Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. Pediatrics. 1997 Jul;100:60-4.

Su WP, Buechner SA, Li CY. Clinicopathologic correlations in leukemia cutis. J Am Acad Dermatol. 1984;11:121-8.

Crist W, Pullen J, Boyett J. Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a pediatric oncology group study. Blood. 1986;67:135-40.

Kaneko Y, Shikano T, Maseki N, Sakurai M, Sakurai M, Takeda T, et al. Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia. 1988;10:672-6.




How to Cite

Kalita, L. K., Kalita, C., Gogoi, P. K., & Sharma, U. C. (2017). Acute T-cell lymphoblastic leukaemia presenting with cutaneous involvement in a child: a rare case report. International Journal of Research in Medical Sciences, 3(5), 1285–1287. Retrieved from



Case Reports