A case of synchronous papillary and clear cell carcinoma in the same kidney


  • Jyoti Shankar Tele Department of Pathology, Saifee Hospital, Mumbai, Maharashtra
  • Anita Shah Department of Pathology, Saifee Hospital, Mumbai, Maharashtra
  • Harshul Kushwaha Department of Pathology, Saifee Hospital, Mumbai, Maharashtra


Renal cell carcinoma, Multifocal, Synchronous, Nephrectomy


Renal Cell Carcinoma (RCC) comprises 2-3% of all cancers. Bilateral coexistent benign and malignant renal tumors have been defined in many reports. However, unilateral synchronous malignant tumors of different histologic subtypes are very rare and only a few such cases have been reported. Herein we describe a 56 year old male patient with coexistent clear cell RCC and papillary RCC in his left kidney that were successfully treated with radical nephrectomy.


Eble JN. Neoplasms. Diseases of the urogenital and reproductive system. In: Damjanov I, Linder J, eds. Anderson’s Pathology. 10th ed. US: Mosby; 1996: 2138-2142.

Rothman J, Crispen PL, Wong Y, Al-Saleem T, Fox E, Uzzo RG. Pathologic concordance of sporadic synchronous bilateral renal masses. Urology. 2008;72(1):138-42.

Patel MI, Simmons R, Kattan MW, Motzer RJ, Reuter VE, Russo P. Long-term follow-up of bilateral sporadic renal tumors. Urology. 2003;61(5):921-5.

Klatte T, Wunderlich H, Patard JJ, Kleid MD, Lam JS, Junker K, et al. Clinicopathological features and prognosis of synchronous bilateral renal cell carcinoma: an international multicentre experience. BJU Int. 2007 Jul;100(1):21-5.

Billings B, Hamrick LC, Bueschen AJ, Kenney PJ. Coexisting angiomyolipoma and renal cell carcinoma in a kidney of an elderly woman: case report and review of the literature. Sci World J. 2004;4(1):27-30.

Kovacs G, Wilkens L, Papp T, de Riese W. Differentiation between papillary and non-papillary renal cell carcinomas by DNA analysis. J Natl cancer Inst. 1989;81:527-30.

Kovacs G. Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases. Am J Pathol. 1989;134:27-34.

Setiwan VW, Stream DO, Nomura AM, Kolonel LN, Henderson BE. Risk factors for renal cell cancer: the multiethnic cohort. Am J Epidemol. 2007;166(8):932-40.

Hunt JD, van derHel OL, McMillan GP, Boffetta P, Brennan P. Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer. 2005;114(1):101-8.

Ali MY, Muir CS, Malignant renal neoplasms in Singapore (survey of incidence, mortality and pathological features). Br J Urol. 1964;36:463-81.

Ljungberg B, Cowan NC, Hanbury DC, Hora M, Kuczyk MA, Merseburger AS, et al. EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol. 2010 Sep;58(3):398-406.

Argani P, Beckwith JB. Renal neoplasms of childhood. In: Mills SE, Carter D, Greenson JK, Reuter VE, Stoler MH, eds. Sternberg’s Diagnostic Surgical Pathology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2010: 1799-1828.

Thoens W, Rumpelt HJ, Störkel S. Classification of renal cell carcinoma and their relationship to nephron-collecting tubules system. Klin Wochenschr. 1990;68(22):1102-11.

Kuroda N, Toi M, Hiroi M, Enzan H. Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18:487-94.

Licht MR, Novick AC, Tubbs RR, Klein EA, Levin HS, Streem SB. Renal oncocytoma: clinical and biological correlates. J Urol. 1993;150(5):1380-3.

Kuroda N, Shiotsu T, Kawada C, Shuin T, Hes O, Michal M, et al. Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma arising in acquired cystic disease of the kidney: an immunohistochemical and genetic study. Ann Diagn Pathol. 2011 Aug;15(4):282-5.

Kang SG, Ko YH, Kang SH, Kim J, Kim CH, Park HS, et al. Two different renal cell carcinomas and multiple angiomyolipomas in a patient with tuberous sclerosis. Korean J Urol. 2010 Oct;51(10):729-32.

Richstone L, Scherr DS, Reuter VR, Snyder ME, Rabbani F, Kattan MW, et al. Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival. J Urol. 2004 Feb;171(2 Pt 1):615-20.

Simhan J, Canter DJ, Sterious SN, Smaldone MC, Tsai KJ, Li T, et al. Pathological concordance and surgical outcomes of sporadic synchronous unilateral multifocal renal masses treated with partial nephrectomy. J Urol. 2013 Jan;189(1):43-7.

Capaccio E, Varca V, Simonato A, Toncini C, Carmignani G, Derchi LE. Synchronous parenchymal renal tumors of different histology in the same kidney. Acta Radiologica. 2009;50(10):1187-92.

Ustuner M, Yaprak B, Teke K, Ciftci S, Kart M, Yildiz K, et al. Coexisting papillary and clear renal cell carcinoma in the same kidney. Case Rep Urol. 2014;2014:575181.




How to Cite

Tele, J. S., Shah, A., & Kushwaha, H. (2017). A case of synchronous papillary and clear cell carcinoma in the same kidney. International Journal of Research in Medical Sciences, 3(5), 1288–1292. Retrieved from https://msjonline.org/index.php/ijrms/article/view/1487



Case Reports