The platelet indices in pediatric patients with acute appendicitis
DOI:
https://doi.org/10.18203/2320-6012.ijrms20150153Keywords:
Appendicitis, Blood platelet, Mean platelet volumeAbstract
Background: The diagnosis of Acute Appendicitis (AA) remains a problem in pediatric population. It has been suggested that Mean Platelet Volume (MPV) is lower in the patients with AA. The purpose of this study was to investigate the diagnostic value of platelet indices in pediatric AA cases.
Methods: A retrospective case-controlled study was designed: 224 subjects were included in this study. All patients had been operated on in division of pediatric surgery at the Kars Government Hospital with the preliminary diagnosis of AA. 204 and 20 of these patients were pathologically diagnosed as AA (group 1) and normal appendix vermiformis (group 2), respectively. Platelet indices had been studied in the biochemistry laboratory of the hospital, before the surgery.
Results: In group 1, platelet count, mean platelet volume, plateletcrit and platelet distribution width were 305 ± 94x103/µL; 7.37 ± 0.90 fL; 0,220 ± 0.057 % and 16.3 ± 0.5%, respectively. In group 2, platelet count, mean platelet volume, plateletcrit and platelet distribution width were 283 ± 85 103/µL; 7.60 ± 1.24 fL; 0.208 ± 0.045 % and 16.4 ± 0.7%, respectively. There was no statistically significant difference between the groups studied with regard to platelet indices (P>0.05).
Conclusions: Our study showed that platelet indices have no diagnostic value in the diagnosis of AA at pediatric age group.
References
Brogden TG, Streets CG. The management of acute appendicitis. J R Nav Med Serv. 2013;99:106-10.
Kim JS. Acute abdominal pain in children. Pediatr Gastroenterol Hepatol Nutr. 2013;16:219-24.
Bundy DG, Byerley JS, Liles EA, Perrin EM, Katznelson J, Rice HE. Does this child have appendicitis? JAMA. 2007;298:438-51.
Danese S, Motte Cd Cde L, Fiocchi C. Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol. 2004;99:938-45.
Pawelski H, Lang D, Reuter S. Interactions of monocytes and platelets: implication for life. Front Biosci (Schol Ed). 2014;6:75-91.
Bilici S, Sekmenli T, Göksu M, Melek M, Avci V. Mean platelet volume in diagnosis of acute appendicitis in children. Afr Health Sci. 2011;11:427-32.
Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A, et al. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost. 2011;17:362-6.
van Heurn LW, Pakarinen MP, Wester T. Contemporary management of abdominal surgical emergencies in infants and children. Br J Surg. 2014;101:e24-33.
Groselj-Grenc M, Repse S, Vidmar D, Derganc M. Clinical and laboratory methods in diagnosis of acute appendicitis in children. Croat Med J. 200;48:353-61.
Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.
Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17:334-41.
Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009;20:277-81.
Akbal E, Demirci S, Koçak E, Köklü S, Başar O, Tuna Y. Alterations of platelet function and coagulation parameters during acute pancreatitis. Blood Coagul Fibrinolysis. 2013;24:243-6.
Beyazit Y, Sayilir A, Torun S, Suvak B, Yesil Y, Purnak T, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol. 2012;36:162-8.
Seker A, Incebiyik A, Kucuk A, Terzi A, Yucel Y, Ciftci R, et al. Mean platelet volume in patients with acute and chronic cholecystitis. Acta Med Mediter. 2013;29:515-9.
Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008;75:291-4.
Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets. 2014;25:81-5.
Tanrikulu CS, Tanrikulu Y, Sabuncuoglu MZ, Karamercan MA, Akkapulu N, Coskun F. Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis. Iran Red Crescent Med J. 2014;16:e10211.
Erdem H, Aktimur R, Cetinkunar S, Reyhan E, Gokler C, Irkorucu O, et al. Evaluation of mean platelet volume as a diagnostic biomarker in acute appendicitis. Int J Clin Exp Med. 2015;8:1291-5.
Uyanik B, Kavalci C, Arslan ED, Yilmaz F, Aslan O, Dede S, et al. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int. 2012;2012:823095.
Narci H, Turk E, Karagulle E, Togan T, Karabulut K. The role of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J. 2013;15:e11934.
Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology. 2006;11:317-9.
