Effect of glycemic status on peripheral nerve conduction in lower limbs in type 2 diabetes mellitus patients

Authors

  • Pranali P. Sonawane Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Swati H. Shah Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Swati H. Shah Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Savita M. Vaidya Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Savita M. Vaidya Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Pradeep S. Nahar Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Pradeep S. Nahar Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Anupam S. Khare Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Anupam S. Khare Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Kiran H. Buge Department of Physiology, B J Govt. Medical College, Pune, Maharashtra
  • Kiran H. Buge Department of Physiology, B J Govt. Medical College, Pune, Maharashtra

DOI:

https://doi.org/10.18203/2320-6012.ijrms20150176

Keywords:

Type 2 diabetes mellitus, Diabetic neuropathy, Nerve conduction study, HbA1c

Abstract

Background: Diabetes mellitus (DM) is one of the most common chronic diseases globally. Diabetic neuropathy is the most common & troublesome complication. But exact pathogenesis is not yet known. Comparatively there are few studies showing relation between glycemic status & diabetic neuropathy. Hence present study was conducted, which was aimed to assess the same in lower limbs in type 2 DM. 

Methods: 60 type 2 diabetes mellitus male patients were selected from diabetic OPD. 30 were having glycated hemoglobin (HbA1c) 6%-9% (group B), 30 were having HbA1c > 9% (group C). They were compared with age and sex matched 30 normal healthy controls (group A). Conduction velocity and amplitude of bilateral sural sensory nerve action potential (SNAP) and peroneal compound muscle action potential (CMAP) were recorded. Glycated hemoglobin was measured using ion exchange resin method.

Results: Group B and group C had significantly lesser means of conduction velocity and amplitude of sural
SNAP (p<0.001) and peroneal CMAP (p<0.05) as compared to group A. Hb A1c had statistically significant
negative correlation with conduction velocity and amplitude of sural SNAP (p<0.001) as well as peroneal CMAP (p<0.001).

Conclusions: This study shows that diabetic patients with higher blood glucose levels are at increased risk of diabetic neuropathy. Diabetic neuropathy in lower limbs worsens with increasing blood glucose levels. Hence stringent action has to be taken at an early stage to control blood glucose levels. Also, patients should be encouraged for regular follow up and strict glycemic control.

 

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Published

2017-01-09

How to Cite

Sonawane, P. P., Shah, S. H., Shah, S. H., Vaidya, S. M., Vaidya, S. M., Nahar, P. S., Nahar, P. S., Khare, A. S., Khare, A. S., Buge, K. H., & Buge, K. H. (2017). Effect of glycemic status on peripheral nerve conduction in lower limbs in type 2 diabetes mellitus patients. International Journal of Research in Medical Sciences, 3(6), 1505–1510. https://doi.org/10.18203/2320-6012.ijrms20150176

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Original Research Articles