Arterial blood gas levels in high altitude Kashmiri population, India

Authors

  • Sheikh Imran Sayeed Department of Physiology, Government Medical College, Srinagar
  • Shazia Handoo Haematology and Transfusion Medicine, Government Medical College, Srinagar
  • Hilal Ahmad Wani Multidisciplinary Research Unit, Government Medical College, Srinagar
  • Nazia Manzoor Walvir Department of Physiology, Government Medical College, Srinagar
  • Qazi Danish Multidisciplinary Research Unit, Government Medical College, Srinagar
  • Rafiq Ahmad Pampori Government Medical College, Srinagar

DOI:

https://doi.org/10.18203/2320-6012.ijrms20151177

Keywords:

PaO2 Partial pressure of oxygen of arterial blood, PaCO2 Partial pressure of carbon dioxide of arterial blood, Kashmir

Abstract

Background: The valley of Kashmir lies at an average height of 1730 m above the sea level with a barometric pressure of 624 mmHg. The fall in atmospheric pressure at higher altitude decreases the partial pressure of inspired oxygen and hence the driving pressure for gas exchange in the lungs. At sea level the normal range of PaCO2 is 35 mmHg to 45 mmHg and at 1500m above sea level (barometric pressure 634 mmHg), the predicted normal PaO2 in a healthy young adult is approximately 80 mmHg; this contrasts with a value close to 95 mmHg at sea level. On these grounds this study was undertaken to formulate normal ABG values for this place as it lies at a higher altitude.

Methods: The study was undertaken to measure "arterial blood gases" (ABG) in ethnic Kashmiri population and consisted of a sample of one hundred healthy Kashmiri subjects of either sex after proper inclusion and exclusion by spirometrically measuring Vital Capacity and Forced expiratory volume in one second/Forced vital capacity (Fev1/FVC). A modified Allen's test was performed to check for adequate collateral circulation ruling out Ischemia.

Results: The average mean PaO2 of 78.51 ± 4.40 mmHg and the average mean PaCO2 of 33.37 ± 2.38 mmHg was obtained of the volunteers of both the sexes. The average mean pH of males (7.43 ± 0.02) was significantly lower than the mean pH of females (7.45 ± 0.021).

Conclusions: The present study might provide useful base line normal values of Arterial Blood Gases for the local population and will be beneficial to the clinicians.

 

References

Guyton AC, Hall JE. Text Book of Medical Physiology. Chapter 30. Regulation of Acid-Base balance. 2006;11:383-401.

Hankins GD, Clark SL, Harvey CJ. Third-trimester arterial blood gas and acid base values in normal pregnancy at moderate altitude. Obstet Gynecol. 1996;88(3):347-50.

McAuliffe F, Kametas N, Karmpl E, Nicolaides K. Blood gases in pregnancy at sea level and at high altitude. BJOG. 2001;108(9):1980-85.

Cerveri I, Zoia MC, Fanfulla F. Reference values of Arterial oxygen tension in the middle aged and elderly. Am. J. Respir. Crit care Med. 1995;152(3):934-41.

Gillics ID, Petrie A, Morgan M, Sykes MK. Analysis of possible factors influencing Pa02 in patients awaiting operation. Br Janaesth. 1977;49(5):427-37.

Guyton AC, Hall JE. Text Book of Medical Physiology. Chapter 39. Physical Principles of gas exchange. 2006;11:491-96.

Sillau AH, Cueva S, Valenzuela A, Candela E.02 transport in the alpaca (Lamapacos) at sea level and at 3,300m. Respir Physiol.1976;27(2):147-55.

Begin R, AD Renzetti jr. Alveolar-Arterial oxygen pressure gradient. Respir Care. 1977;22:491-500.

Andrews JL Jr, Copeland BE, Salah RM, Morrissey B, Enos EJ, Spilios A. Arterial blood gas standards for healthy young non-smoking subjects. Am J. Clinical Pathology. 1981;75(6):773-80.

Malmberg P, Hedenstorm H, Fridriksson HV. Reference values for gas exchange during exercise in healthy non-smoking and smoking men. Bull Eur Physiopathology Respir. 1987;23(2):131-38.

Crapo RA, Jensen RL, Hegewald M, Tashkin DP. Arterial blood gas reference values for sea level and an altitude of 1,400m. Am J Respir Crit Care Med. 1999;160(5):1525-31

Sorbini LA, Grass V, Solinas E.Arterial Oxygen tension in relation to age in healthy subjects. Respiration. 1968;25:3-13.

Hardie JA, Morkve O, Ellingsen I. Effects of body position on arterial oxygen tension in the elderly. Respiration. 2002;69:123-28.

Guenard H, Marthan R. Pulmonary gas exchange in elderly. Eur Respir J. 1996;9:2573-77.

Hardie JA, Vollmer VM, Buist S, Ellingsen I, Morkve O. Reference valves for arterial blood gases in the elderly. Chest. 2004;125:2053-60.

Hansen JE, Casaburi R. Patterns of dissimilarities among instruments models in measuring P02, PCO2 and pH in blood gas laboratories. Chest. 1998;113:780-87.

Raine JM, Bishop JM. A-a difference in 02 tension and physiologic dead space in normal man. J. Appl. Physiol. 2001;18:284-88.

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Published

2017-01-16

How to Cite

Sayeed, S. I., Handoo, S., Wani, H. A., Walvir, N. M., Danish, Q., & Pampori, R. A. (2017). Arterial blood gas levels in high altitude Kashmiri population, India. International Journal of Research in Medical Sciences, 3(11), 3283–3287. https://doi.org/10.18203/2320-6012.ijrms20151177

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Original Research Articles