Carbimazol and acenocoumarol, where is the problem?

Authors

  • Naoual El Omri Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Fadwa Mekouar Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Rachid Eljaoudi Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Mohamed Jira Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Youssef Sekkach Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Taoufik Amezyane Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco
  • Driss Ghafir Department of Internal Medicine, Military Teaching Hospital Mohamed V, University Mohammed V, Rabat, Morocco

DOI:

https://doi.org/10.18203/2320-6012.ijrms20171294

Keywords:

Acenocoumarol, Carbimazole, Drug interactions

Abstract

Acenocoumarol and carbimazole are two drugs widely prescribed, they can sometimes be used in the same time. There is no known drug interaction between the two drugs but we report a case of a serious hemorrhagic complication following the concomitant use of the acenocoumarol and carbimazole. A 70-year old man treated by acenocoumarol for an aortic and mitral valve replacement. For a clinical and biological hyperthyroidism, he began treatment with carbimazole, ten days before admission. Three days later, he developed a mucocutaneous icterus with major hemorrhagic syndrome. The outcome was favourable after stopping medication and the use of vitamin K.

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Published

2017-03-28

How to Cite

El Omri, N., Mekouar, F., Eljaoudi, R., Jira, M., Sekkach, Y., Amezyane, T., & Ghafir, D. (2017). Carbimazol and acenocoumarol, where is the problem?. International Journal of Research in Medical Sciences, 5(4), 1709–1711. https://doi.org/10.18203/2320-6012.ijrms20171294

Issue

Section

Case Reports