The study of lipid profile, LP (a) and electrolytes with oxidative stress, total protein and albumin in nephrotic syndrome

Authors

  • Jyoti Dwivedi Department of Biochemistry, S.S. Medical College, Rewa - 4860001, M.P.
  • Purnima Dey Sarkar Department of Biochemistry, M.G.M. Medical College, Indore, M.P.

Keywords:

Nephrotic syndrome (NS), Total antioxidant capacity (TAC), Malondialdehyde (MDA), Total cholesterol (Tchol)

Abstract

Nephrotic syndrome is characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia associated with peripheral edema. Recent observation revealed that serum albumin plays an important role in the host defense mechanism as it is one of the important antioxidants. Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Therefore, this study was carried out to investigate oxidant and lipoprotein (a) status with protein and electrolytes in nephrotic syndrome patients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipid peroxide, total antioxidant capacity, lipid profile, lipoprotein (a), electrolytes, total protein and albumin. Significantly increased levels of serum lipid peroxide, lipoprotein (a) LDL, VLDL, Tcholand decreased levels of serum total antioxidant capacity and total protein and albumin were noticed in the patients with nephrotic syndrome as compared to control subjects. Electrolytes are variable Na was increased and potassium was decreased. However, significant positive correlation in lipid peroxide with lipoprotein (a),and total protein and albumin with total antioxidant capacity were observed.

References

Togawa A, Yamamoto T, Hishida A. Nephrotic syndrome: pathophysiology, classification and diagnostic criteria. Nippon Rinsho 2004;62(10):1777-83.

Mouline B, Ollier S, Olmer M. Disturbances of lipid metabolism during nephrotic syndrome. Nephrology 1992;13(5):193-9.

Pati U, Pati N. Lipoprotein (a), atherosclerosis, and apolipoprotein (a) gene polymorphism. Mol Genet Metab 2000 Sep-Oct;71(1-2):87-92.

Rifai N. Lipoproteins and apolipoproteins. Composition, metabolism and associated with coronary heart disease. Arch Pathol Lab Med 1986;110:694-704.

Perico N, Remuzzi G. Renal handling of sodium in the nephrotic syndrome. Am J Nephrol 1993;13(5):413-21.

Querfeld U. Should hyperlipidemia in children with the nephrotic syndrome be treated? Pediatr Nephrol. 1999 Jan;13(1):77-84.

Dogra G, Ward N, Croft KD, Mori TA. Oxidant stress in nephrotic syndrome: comparison of F(2)-isoprostanes and plasma antioxidant potential. Nephrol Dial Transplant. 2001 Aug;16(8):1626-30.

Ece A, Atamer Y, Gürkan F, Bilici M, Koçyiğit Y. Anti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome. Nephrology (Carlton). 2004 Dec;9(6):366-73.

Koracevic D, Koracevic G, Jordjevic VD et al. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 2001;54:356-61.

Hunter MI, Nlemadin BC, Davidson DL. Lipid peroxidation product and antioxidant activity in plasma. Neuroscience 1985;10:1645-52.

Roe JH, Kuether CA. The determination of ascorbic acid in the whole blood and urine through the 2,4dinitrophenylhydrazine derivative of dehydroascorbic acid. J Biol Chem 1943;147:399-407.

Appel GB, Valeri A, Appel AS, Blum C. The hyperlipidemia of the nephrotic syndrome. Am J Med. 1989 Nov;87(5N):45N-50N.

Appel GB, Blum CB, Chien S. The hyperlipidemia of the nephrotic syndrome. Relation to plasma albumin concentration, oncotic pressure, and viscosity. N Engl J Med. 1985 Jun;312(24):1544-8.

DeKaysen GA, Barrett HA. Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis. Kidney Int. 1998 Apr;53(4):994-1001.

Shearer GC, Kaysen GA. Proteinuria and plasma compositional changes contribute to defective lipoprotein catabolism in the nephrotic syndrome by separate mechanisms. Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S119-22.

Doucet A, Favre G, Deschênes G. Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications. Pediatr Nephrol. 2007 Dec;22(12):1983-90.

Perico N, Remuzzi G. Renal handling of sodium in the nephrotic syndrome. Am J Nephrol. 1993;13(5):413-21.

Siddall EC, Radhakrishnan J. The pathophysiology of edema formation in the nephrotic syndrome. Kidney Int. 2012 Sep;82(6):635-42.

Donckerwolcke RA, France A, Raes A, Vande Walle J. Distal nephron sodium-potassium exchange in children with nephrotic syndrome. Clin Nephrol. 2003 Apr;59(4):259-66.

Kronenberg F, Lingenhel A, Lhotta K, Rantner B et al. The apolipoprotein (a) size polymorphism is associated with nephrotic syndrome. Kidney Int. 2004 Feb;65(2):606-12.

Li HQ, Wu J, Niu DM, Shi YH. The level of native and oxidized lipoprotein (a) in children with nephrotic syndrome. Clin Biochem. 2012 Jan;45(1-2):101-5.

Noto D, Barbagallo CM, Cascio AL, Cefalù AB et al. Lipoprotein (a) levels in relation to albumin concentration in childhood nephrotic syndrome. Kidney Int. 1999 Jun;55(6):2433-9.

Bulucu F, Vural A, Aydin A, Sayal A. Oxidative stress status in adult with nephrotic syndrome. Clin Nephrol 2000;53:169-73.

Coroba PA, Sanchez Q JL, Gozalez SF et al. Susceptibility of plasma low and high density lipoproteins to oxidation in patients with severe atherosclerosis. J Mol Med 1996;74(12):705-6.

EI Melegy NT, Mohammed NA, Sayed MM. Oxidative modification of low density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome. Pediatr Res 2008;63(4):404-9.

Skrzep-poloczec B, Tomasik A, Tarnawski R, Hyla-Hyla-Klekot L, Dyduch A, Wojcie Chowska C, Wesolowski W, Kopieczna GE, Zalejska FJ, Widera E. Nephrotic origin hyperlipidemia, relation-reduction of Vitamin E level and subsequent oxidative stress may promote atherosclerosis. Nephron 2001;89(1):68-72.

Kaneko K, Kimata T, Tsuji S, Shimo T, Takahashi M, Tanaka S. Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome. Clin Exp Nephrol. 2012 Jun;16(3):411-4.

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Published

2017-01-20

How to Cite

Dwivedi, J., & Sarkar, P. D. (2017). The study of lipid profile, LP (a) and electrolytes with oxidative stress, total protein and albumin in nephrotic syndrome. International Journal of Research in Medical Sciences, 2(1), 62–66. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2060

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Original Research Articles