Acute intermittent porphyria with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and neurological crisis, successfully treated with haemodialysis

Authors

  • P. S. Singh Department of Medicine, UP Rural Institute of Medical Sciences & Research (UPRIMS&R), Saifai, Etawah - 206130, UP
  • Ramakant Rawat Department of Medicine, UP Rural Institute of Medical Sciences & Research (UPRIMS&R), Saifai, Etawah - 206130, UP
  • K. S. Zafar Department of Medicine, UP Rural Institute of Medical Sciences & Research (UPRIMS&R), Saifai, Etawah - 206130, UP

Keywords:

Acute porphyria, Antidiuretic hormone, Hyponatremia

Abstract

We report a 35 years old male, a case of Acute Intermittent Porphyria (AIP) with Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) and neurological crisis for its rarity. Since specific parenteral medication (hemin) was not available, patient was empirically treated with haemodialysis with satisfactory outcome.

References

Usalan C, Erdem Y, Altun B, Gurosy M, Celik I, Yasavul U, Turngan C, Caglar S. Severe hyponatremia due to SIADH provoked by acute intermittent porphyria. Clin Nephrol. 1996;45:418.

Anderson KE, Bloomer JR, Bonkovsky HL, Kushner JP, Pierach CA, Pimstone NR, Desnick RJ. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Intern Med. 2005;142:439-50.

Frere T, Roy-Peaud F, Ripault MP, et al. Acute intermittent porphyria associated with hyperaldosteronism and inappropriate antidiuretic hormone secretion syndrome. Gastroenterol Clin Biol. 1998;22:727-31.

Fares RV, Kart SJ, Boot-Lopez P. Acute intermittent porphyria associated with inappropriate anti-diuretic hormone secretion, hypokalemic alkalosis and secondary hyperaldosteronism. South Med J. 1979;72:120-2.

Ignacy W, Wiecek A, Kokot F. Haemodialysis: is it a method of acute intermittent porphyria treatment? Case report. Pol Arch Med Wewn. 1999;101:55-8.

Herrick AL, McColl KE. Acute intermittent porphyria. Best Pract Res Clin Gastroenterol. 2005;19:235-49.

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Published

2017-01-23

How to Cite

Singh, P. S., Rawat, R., & Zafar, K. S. (2017). Acute intermittent porphyria with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and neurological crisis, successfully treated with haemodialysis. International Journal of Research in Medical Sciences, 2(2), 795–797. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2253

Issue

Vol. 2 No. 2 (2014): April-June 2014

Section

Case Reports