Varicella-zoster virus transverse myelitis in an immunocompetent patient
Keywords:
Varicella-zoster virus, Transverse myelitis, ImmunocompetentAbstract
Transverse myelitis is one of the rare neurological complications of Varicella-Zoster Virus (VZV) infection in immuno-competent. We report a 26-year-old immuno-competent gentleman who developed virologically confirmed myelopathy caused by VZV which improved with steroids and acyclovir leaving no residual neurological deficits.
References
Steiner I, Kennedy PG, Pachner AR. The neurotropic herpes viruses: herpes simplex and varicella-zoster. Lancet Neurol. 2007;6:1015-28.
Tavazzi E, Minoli L, Ferrante P, Scagnelli P, Del Bue S, Romani A et al. Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient. Neurol Sci. 2008;29:279-83.
LaRovere KL, Raju GP, Gorman MP. Postvaricella acute transverse myelitis is a previously vaccinated child. Pediatr Neurol. 2008;38:370-2.
Kleinschmidt-DeMasters BK, Gilden DH. Varicella zoster virus infections of the nervous system: clinical and pathologic correlates. Arch Pathol Lab Med. 2001;125:770-80.
Jubelt B, Miller J. Viral infections. In: Lewis P. Rowland, Timothy A. Pedley, eds. Merritt’s Neurology. 10th ed. Philadelphia: WB Saunders; 2001: 152.
Gilden D, Nagel MA, Mahalingam R, Mueller NH, Brazeau EA, Pugazhenthi S et al. Clinical and molecular aspects of varicella virus infection. Future Neurol. 2009;4:103-17.
Mayo D, Booss J. Varicella zoster-associated neurologic disease without skin lesions. Arch Neurol. 1989;46:313-5.
Gelb LD. Varicella-zoster virus. In: Fields BN, Knipe DM, Chanock RM et al., eds. Virology. 1st ed. New York: Raven Press; 1990: 2011-2054.
Hogan EL, Krigman MR. Herpes zoster myelitis. Evidence for viral invasion of spinal cord. Arch Neurol. 1973;29:309-13.
Hwang YM, Lee BI, Chung JW et al. A case of herpes zoster myelitis: positive magnetic resonance imaging finding. Eur Neurol. 1991;131:164-7.
Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurol. 2008;70:853-60.
Defresne P, Meyer L, Tardieu M, Scalais E, Nuttin C, De Bont B et al. Efficacy of high dose steroid therapy in children with severe acute transverse myelitis. J Neurol Neurosurg Psychiatr. 2001;71:272-4.