Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

Authors

  • Maram Sushma Department of Biochemistry, Narayana Medical College, Chintareddypalem, Nellore- 524003, Andhra Pradesh
  • Krishnan Ramalingam Department of Biochemistry, Narayana Medical College, Chintareddypalem, Nellore- 524003, Andhra Pradesh
  • Jupalli N. Naidu Department of Biochemistry, Narayana Medical College, Chintareddypalem, Nellore- 524003, Andhra Pradesh
  • Tatireddy V. Lakshmi Department of Biochemistry, Narayana Medical College, Chintareddypalem, Nellore- 524003, Andhra Pradesh

Keywords:

Hypothyroidism, Dyslipidemia, TSH, Cholesterol, Fasting blood sugar

Abstract

Background: Hypothyroidism has become a highly prevalent condition worldwide as well as in India. Females are affected more than men and dyslipidemia has been associated with hypothyroidism. This study was conducted to study the prevalence and pattern of dyslipidemia in hypothyroid patients and to justify the screening of lipid profile in hypothyroid patients.

Methods: This was a case control study which included 50 newly diagnosed and untreated hypothyroid patients and 50 healthy individuals in the age group of 20-40years. Free Triiodothyronine (FT3), free thyroxine (FT4), Thyroid Stimulating Hormone (TSH) were estimated by chemiluminiscence immunoassay.Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), blood glucose were done in all the subjects by enzymatic colorimetric method. Low density lipoprotein cholesterol (LDL-C) was calculated using Friedwalds formula. Very Low density lipoprotein cholesterol (VLDL-C) was calculated from the triglyceride value.

Results: Lipid profile alterations were seen in hypothyroid patients. The mean (standard deviation)values of Total cholesterol, high density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Very Low density lipoprotein cholesterol (VLDL-C), triglycerides (TG), Fasting blood glucose were 183.7 (32.9), 38.12 (7.59), 104.4 (29.42), 31.66 (13.09), 158.44 (65.61), 95.9(9.9) mg/dl respectively. The statistical analysis showed that the difference in the above values between cases and controls was significant and all the mean values except HDL-C were increased in cases.

Conclusions: Hypothyroid patients demonstrate significant increase in serum lipids as compared to healthy individuals. More females are diagnosed with hypothyroidism and dyslipidemia is associated with primary hypothyroidism.

 

References

Seely, E.W., Williams, G.H. (2001) The heart in Endocrine Disorder In: Eugene Braunwald, Douglas P. Zipes ed. Heart Disease 6th edition. W.B. Saunders Company, Philadelphia.p.2151-2171.

Shaikh Z. Thyroid related disorders at CHK. JCPSP. 1993; 3:26-8.

Toft A. Hypothyroidism. Med Intern 1989; 8:2596-2600.

Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. Journal of Clinical Endocrinology. Metabolism. 2003; 88:2438-2444.

Jawed S, Khawaja TF, Sultan A. Mahmood. Alterations in lipid profile in old age hypothyroid patients. Ann. King Edward Med. Coll. Sep. 2005;11(3):311-313.

Dixit AK, Dey R, Suresh A, Mitra A Upadhyaay SN, Hazra J. Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital. International Journal of Biomedical Research.2014;05 (04).

Regmi A, Shah B, Rai BR, Pandeya A. Serum lipid profile in patients with thyroid disorders in central Nepal. Nepal Medical College Journal, 2010;12(4): 253-256.

Sisk J. Thyroid disease in women. Thyroid, 2005; 17:34-8.

Limbu YR, Rai SK, Ono K et al. Lipid profile of adult Nepalese population. Nepal Medical College Journal, 2008; 1:4-7.

Alexander, J.G.H., Bindels, R.G.J., Frolich, W.M. The Prevalence of sub clinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case finding? Clin. Endocrinol. 1999; 50:217-220.

Miura, S., Iitaka, M., Yoshimura, H. Disturbed lipid Metabolism in patients with sub clinical Hypothyroidism: Effect of L-thyroxine therapy. Inter. Med. 1994;33(7).

Kuusi T, Taskinen MR, Nikkila EA. Lipoproteins, lipolytic enzymes and hormonal status in hypothyroid women at different levels of substitution. J Clin Endocrinol Metab.1988; 66:51–56.

O’Brien T, Dinneen SF, O’Brien PC, Palumbo PJ. Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin Proc.1993; 68:860–866.

Leonidas H. Duntas, MD, Gabriela Brenta, MD. The Effect of Thyroid Disorders on Lipid Levels and Metabolism. Med Clin N Am96.2012;269–281.

Liberopoulos E N,Elisaf M S. Dyslipidemia in patients with thyroid disorders. Hormones 2002;1(4):218-223.

Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG, et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Archives of Internal Medicine, 2000; 160:1573157-5.

Mouradian M, Abourizk N. Diabetes mellitus and thyroid disease. Diabetes Care, 1983; 6:512-520.

Satish R, Mohan V. Diabetes and thyroid diseases: a review. International Journal of Diabetes in Developing Countries, 2003; 23(4):120-123.

Brenta G. Diabetes, thyroid disorders. British Journal of Diabetes and Vascular Diseases, 2010; 10:172-177.

Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: Clinical implications and screening strategies. Int J Clin Pract. 2010 Jul;64(8):1130-9.

Downloads

Published

2017-01-26

How to Cite

Sushma, M., Ramalingam, K., Naidu, J. N., & Lakshmi, T. V. (2017). Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism. International Journal of Research in Medical Sciences, 2(4), 1694–1698. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2487

Issue

Section

Original Research Articles