Mucinous carcinoma of breast with neuroendocrine differentiation: a rare case report with review of literature

D. Anuradha, A. Bhagya Lakshmi


Mucinous carcinoma of the breast is a relatively rare malignancy accounting for 2% of all breast cancers. Mucinous carcinoma of the breast has a favourable prognosis and is usually seen in postmenopausal women. Here, we report a 60 year old female patient presented with right breast lump was diagnosed on cytology as ductal carcinoma of the breast, on histopathology diagnosed as mucinous carcinoma with neuroendocrine differentiation, which was subsequently confirmed on IHC marker synaptophysin and chromogranin A positive.


Breast, Mucinous breast carcinoma, Neuroendocrine differentiation

Full Text:



Mitsuaki Ishida, Tomoko Umeda, Hajime Abe, Tohru Tani, Hidetoshi Okabe. Neuroendocrine carcinoma of the breast with a mucinous carcinoma component: A case report with review of the literature. Oncology letters 2012;4: 29-32.

Tavassoli FA, Devilee P. Pathology and Genetics: Tumours of the Breast and Female Genital Organs. WHO Classification of Tumours series, Volume 4. 3rd edition. Lyon, France: IARC Press; 2003:32-34.

Toikkanen S, Kujari H. Pure and mixed mucinous carcinomas of the breast: a clinicopathologic analysis of 61 cases with long-term follow-up. Hum Pathol 1989; 20: 758–64.

Cai RX & Seng X. Clinical and pathological analysis of 13 cases of primary neuroendocrine carcinoma in breast. Tumour J World 2008;7:268-70.

Silverberg SG, Kay S, Chitale AR, Levitt SH. Colloid carcinoma of the breast. Am J ClinPathol 1971;55:355-63.

Rosen PP. Mucinous carcinoma. In, Rosen PP (ed.) Rosen’s Breast Pathology, 1st edition. Philadelphia, Lippincott-Raven, 1997; 405-420.

Sapino A, Righi L, Cassoni P, Capotti M, Pietribiasi F, Bussolati G. Expression of the neuroendocrine phenotype in carcinoma of the breast. Semin Diagn Pathol 2000; 17; 127-37.

López-Bonet E, Alonso-Ruano M, Barraza G, Vazquez-Martin A, Bernadó L, Menendez JA. Solid neuroendocrine breast carcinomas: incidence, clinico-pathological features and immunohistochemical profiling. Oncol Rep. 2008; 20(6):1369-74.

Nesland JM, Holm R, Jhonannessen JV, Gould VE. Neuroendocrine differentiation in breast lesions. Path Resp Pract 1988; 183:214-21.

Upalakalin JN, Collins LC, Tawa N, Parangi S. Carcinoid tumors in the breast. Am J Surg 2006; 191(6):799-805.

Takehiro F, Masahiro K, Kazuhiro S, Yuka K, Moto Y, Hiroshi Y et al: A case of neuroendocrine carcinoma of the breast. Hokkaido J Surg 2006; 51(1): 23-26.

Lacroix-Triki, M., Suarez, PH., MacKay, A., Lambros, MB., Natrajan, R., Savage, K., Geyer, FC., Weigelt, B., Ashworth, A. & Reis-Filho, JS. Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. J Pathol 2010;222(3): 282-98.