Changes in WBC and platelet count in patients with malaria: a hospital based comparative study

Amit S. Jojera, Rasik N. Hathila, Prashant R. Patel, Hemali J. Tailor

Abstract


Introduction: Malaria is one of the most common infectious diseases of tropics. It presents with varied clinicopathological manifestations. Most of the complication in malaria occurs due to various hematological abnormalities. Present study was aimed to find out abnormalities in WBC and platelet counts in patients with malaria. Methods: A total 135 patients either hospitalized or treated on an outpatient basis were included in the study after positive identification for malarial parasites on Giemsa stained PSMP smears. WBC and platelet count was carried out on 3 part hematology analyzer (Sysmax KX 21). WBC count less than 4000/cumm was considered as leucopenia and platelet count less than 150000/cumm was considered as thrombocytopenia.

Results: The present study includes 135 patients with malaria from which 72.59% of subjects were male and 27.41% of subjects were female. P. falciparum was present in 68.89% of cases, P. vivax in 28.15% of cases. Majority of patients had normal leucocyte count (97.03%). Neutrophilia with lymphopenia was observed in both species of malaria in our study. Thrombocytopenia was observed in89.62% of cases in malaria. Thrombocytopenia in P. falciparum was found in 92.48% of cases and in P. vivax it was 81.57% of cases.

Conclusion: Present study did not show any significant change in WBC count. Present study showed neutrophilia with relative lymphopenia in both group of malaria. Incidence of thrombocytopenia was observed in both species of malaria without any statistical significance.

 


Keywords


Neutrophilia, Lymphopenia, Thrombocytopenia

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References


World Health Organization. Fact sheet: World Malaria Report 2012.Embargoed 2012. Available from: http://www.who.int/malaria/publications/ world_malaria_report_2012/wmr2012_factsheet.pdfAssessed on 22 June 2013.

Dastur FD. The changing scenario of malaria in India. Journal of the Association of Physicians India. 2012;60:9.

Shetty GM, Bhandary N. Leucocyte count as a marker of severity in malaria. International Journal of Biomedical Research 2012;3(2):88-90.

Akhtar S, Gumashta R, Mahore S, Maimoon S. Hematological changes in malaria: A comparative study. IOSR Journal of Pharmacy and Biological Science. 2012;2(4):15-19.

Faseela TS. Diagnostic value of platelet count in malaria. Journal of Clinical and Diagnostic Research 2011;5(3):464-66.

Shrikant J, Srinivas S, Krishna C, Ramulu PR. Prevalence of thrombocytopenia in a diagnosed case of malaria in rural population of South India. Journal of Dr. NTR University of Health Science 2012;1(3):152-55.

Jadhav UM, Patkar VS, Kadam NN. Thrombocytopenia in malaria- Correlation with type and severity of malaria. Journal of the Association of Physician India August 2004;52:615-18.

Bhavna S, Bharti A, Yogesh K, Aggrawal R. Parasitemia and haematological alteration in malaria: A study from the highly affected zones. Iranian Journal of Pathology 2013;8(1):1-8.

Jadhav UM, Singhvi R, Shah R. Prognostic Implications of White Cell Differential Count and White Cell Morphology in Malaria. J Postgrad Med 2003;49(3):218-21.

Limaye CS, Londhery VA, Nabar ST. The study of complications of vivax malaria in comparision

with falciparum malaria in Mumbai. Journal of

the Association of Physician India October 2012;60:15-17.

Ranjini CY, Roopa M, Wilma Delphine Silva CR, Santosh KV. Evaluation and comparison of hematological parameters between Vivax and Falciparum malaria. Int J Pharm Bio Sci 2012 Oct; 3(4):(B)1120-28.

Kelton JG, Keystone J, Moore J, Denomme G, Tozman E, Glynn M, et al. Immune mediated thrombocytopenia in malaria. J Clin Invest 1983;71:832-36.

Katira B, Shah I. Thrombocytopenia in plasmodium vivax infected children. Journal of Vector Borne Disease 2006;43:147-49.

Colonel KMU, Devrajani BR, Shaikh K, Shaikh KR, Shah SZA. Severity of thrombocytopenia and prolonged bleeding time in patients with malaria (A clinical study of 162 malaria cases). World Applied Science Journal 2010;9(5):484-88.

Shaikh MA, Ahmed S, Diju IU, Yakta DE. Platelet count in malaria patients. J Ayub Med Coll Abbottabad 2011;23(1):143-45.

Solanki R, Thakral R, Shipra, Vrashney A, Agrawal A. Thrombocytopenia in malaria. Journal of Advance Research in Medical Science 2012;4(1):65-67.

Dhunghat MP, Dhunghat PP. Thrombocytopenia in patients of malaria. Online International Interdisciplinary Research journal 2013;3(2):21-25.

Sheikh QH, Ahmed SA, Abbasi A, Malik SA, Sohito AA, Munir SM. Thrombocytopenia in malaria. Journal of college of physician and surgeons Pakistan 2009;19(11):708-10.

Makkar RPS, Mukhopadhyay S, Monga A, Gupta AK. Plasmodium vivax malaria presenting with severe thrombocytopenia. The Brazilian journal of Infectious disease 2002;6(5):263-65.