Solitary Langerhans cell histiocytosis of liver with sclerosing cholangitis in an adult female

Authors

  • Nazneen A. Kader Department of Pathology, Government Medical College, Kozhikode, Kerala, India
  • Indusarath S. Department of Pathology, Government Medical College, Kozhikode, Kerala, India
  • N. K. Supriya Department of Pathology, Government Medical College, Kozhikode, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20171876

Keywords:

Adult LCH, Liver LCH, Sclerosing cholangitis

Abstract

Liver is affected as a late complication of high risk cases of Langerhans cell histiocytosis. Sclerosing cholangitis is a rare pattern associated with Langerhans cell histiocytosis of liver, which is even rarer in the adult population and has high mortality. The treatment is difficult and may require liver transplantation. We report a unique case of a 40-year-old female who developed sclerosing cholangitis associated with Langerhans cell histiocytosis without any evidence of involvement of other systems. Our patient required only surgery, and had been followed up for two years without recurrence. We could not find any other case of solitary liver involvement of Langerhans cell histiocytosis in literature published so far.

References

Kaplan KJ, Goodman ZD, Kamal GI. Liver involvement in Langerhans' cell histiocytosis: a study of nine cases. Modern pathology. 1999;12:370-8.

Abdallah M, G´en´ereau T, Donadieu J. Langerhans’ cell histiocytosis of the liver in adults. Clin Res Hepatol Gastroenterol. 2011;35(6-7):475-81.

Hatemi I, Baysal B, Senturk H, Behzatoglu K, Bozkurt ER, Ozbay G. Adult Langerhans cell histiocytosis and sclerosing cholangitis: a case report and review of the literature. Hepatol Int. 2010;4(3):653-8.

Histocyte Society 2009. Langerhans cell histiocytosis evaluation and treatment guidelines. Histocyte Society online, 2009, cited 2010-02. Avaliable at https://histiocytesociety.org/ document.doc?id=290

Braier J, Ciocca M, Latella A, de Davila MG, Drajer M, Imventarza O. Cholestasis, sclerosing cholangitis, and liver transplantation in Langerhans cell histiocytosis. Medical and pediatric oncology. 2002;38(3):178-82.

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Published

2017-04-26

How to Cite

Kader, N. A., S., I., & Supriya, N. K. (2017). Solitary Langerhans cell histiocytosis of liver with sclerosing cholangitis in an adult female. International Journal of Research in Medical Sciences, 5(5), 2237–2239. https://doi.org/10.18203/2320-6012.ijrms20171876

Issue

Section

Case Reports