Dengue infection in central India: a 5 years study at a tertiary care hospital

Authors

  • Smita T. Deshkar Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Sharmila S. Raut Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
  • Ravindra K. Khadse Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172433

Keywords:

Central India, Dengue, Seropositivity, Thrombocytopenia

Abstract

Background: Dengue is one of the most important mosquito borne viral disease with wide spectrum of clinical presentation and often with unpredictable clinical evolution and outcome. Approximately 50 million infections occur annually world-wide, but what’s the real size of the problem in India?  Nobody truly knows...!!  Present study was carried out to determine seropositivity, clinical profile and seasonal variation of dengue infection in central India.

Methods: Study was carried out from January 2012 to December 2016. Blood samples were collected from 15,606 patients with dengue like clinical illness and serum was separated. All the samples were subjected to IgM antibody detection by dengue MAC ELISA.

Results: Prevalence of dengue in dengue suspected cases was found to be 24.49% (3,822/15,606). Maximum number of positive cases, 1,548 (40.50%) were in the age group of 0-10 years. Males (60.83%) were affected more than females (39.17%). Peak was observed in the months of August, September, October and November. Common presenting features were fever followed by myalgia, arthralgia, headache and bleeding manifestations. Significant drop in platelet count was observed in patients with dengue shock syndrome and dengue haemorrhagic fever.

Conclusions: Number of dengue cases in central India are on increase and continued surveillance is essential to determine epidemiological and seasonal trend.

Author Biographies

Smita T. Deshkar, Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

Assistant Professor, Department of Microbiology,

Indira Gandhi Government Medical College, CA Road,

Nagpur -440018

Maharashtra

Sharmila S. Raut, Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

Professor and Head,
Department of Microbiology,
Indira Gandhi Government Medical College, Nagpur,
Maharashtra, India.

Ravindra K. Khadse, Department of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

Associate Professor,
Department of Microbiology,
Indira Gandhi Government  Medical College, Nagpur,
Maharashtra, India

References

prevention and control. New edition Geneva: World Health Organization. 2009.

Shepard DS, Halasa YA, Tyagi BK, Adhish SV, Nandan D, Karthiga KS, et al. Economic and Disease Burden of Dengue Illness in India. Am J Trop Med Hyg. 2014; 91(6):1235-42.

Mandell, Doughlas and Bennett’s principle and practice of infectious diseases, Vol 2, 7th ED, Churchill Livingstone Elsevier, Philadelphia.2010: 2133-56.

Normile D. Surprising new dengue virus throws a spanner in disease control efforts. Science. 2013;342(6157):415.

Johansson MA, Dominici F, Glass GE. Local and global effects of climate on dengue transmission in Puerto Rico. PLoS Negl Trop Dis. 2009;3(2):e382.

Ukey PM, Bondade SA, Paunipagar PV, Powar RM, Akulwar SL. Study of seroprevalance of dengue fever in central India. Indian J Community Med. 2010;35(4):517-9.

Guidelines for clinical management of dengue fever, dengue hemorrhagic fever, dengue shock syndrome. Delhi: Ministry of Health and Family Welfare; 2008. Available at http://www.nvbdcp.gov.in/ Doc/Clinical%20Guidelines.pdf:

WHO guidelines on drawing blood: Best practices in phlebotomy. WHO, Geneva. 2010.

Centers for Disease Control and Prevention Available at http://www.cdc.gov/dengue/ resources/ dengueCase Reports/DCIF_English.pdf

Saini S, Kinikar AG, Deorukhkar S, Bhalerao D, Roushani SB. Epidemiology and seropositivity of dengue fever cases in a rural tertiary care hospital of western Maharashtra, India. Int J Bio Med Res.2013;4(7):473-7.

Sood S. A hospital based serosurveillance study of dengue infection in Jaipur (Rajasthan). India. J Clin Diagn Res. 2013;7(9):1917-20.

Rao MS, Pavani K, Dass M, Kareem MA, Vinayaraj EV. Seroprevalence of dengue virus in a tertiary care hospital, Andhra Pradesh, South India. Int J Res Med Sci. 2013;1(4):448-50.

Kumar A, Rao CR, Pandit V, Shetty S, Bammigatti C, Samarasinghe CM. Clinical manifestations and trend of dengue cases admitted in a tertiary care hospital, Udupi district, Karnataka. Indian J Community Med. 2010;35(3):386-90.

Guzman MG, Sierra B, Kouri G, Farrar J, Simmons C. Host and Virus Determinants of Susceptibility and Dengue Disease. Frontiers in dengue virus research. 2010:79-102.

Karoli R, Fatima J, Siddiqi Z, Kazmi K, Sultania A. Clinical profile of dengue in India. J Infect Dev Ctries. 2012;6(7):551-4.

Murugananthan K, Kandasamy M, Rajeshkannan N, Noordeen F. Demographic and clinical features of suspected dengue and dengue haemorrhagic fever in the Northern Province of Sri Lanka, a region afflicted by an internal conflict for more than 30 years-a retrospective analysis. Int J Infect Dis. 2014; 27:32-6.

Halstead SB, Nimmannitya S, Cohen SN. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med. 1970;42(5):311-28.

Sapir DG, Schimmer B. Dengue fever: new paradigms for a changing epidemiology. Emerging Themes in Epidemiol. 2005;2(1):1.

Gunasekaran P, Kaveri K, Mohana S, Arunagiri K, Suresh Babu BV, Padma Priya P, et al. Dengue disease status in Chennai (2006-2008): A retrospective analysis. Indian J Med Res. 2011; 133(3):322-5.

Centers for Disease Control and Prevention. Available from http://www.cdc.gov/Dengue.

Turbadkar D, Ramchandran A, Mathur M, Gaikwad S. Laboratory and clinical profile of dengue: A study from Mumbai. Ann Trop Med Public Health. 2012;5(1):20-3.

Mandal SK, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Sarkar P, et al. Clinical profiles of dengue fever in a teaching hospital of eastern India. Nat J Med Res. 2013;3(2):173-6.

Khan MU, Rehman R, Gulfraz M, Latif W. Incidence of thrombocytopenia in seropositive dengue patients. Int J Med Sci. 2014;6(4):113-6.

Khan DM, Kuppusamy K, Sumathi S, Mrinalini VR. Evaluation of thrombocytopenia in dengue infection along with seasonal variation in rural Melmaruvathur. J Clin Diagn Res. 2014;8(1):39-42.

Kauser M, Kalavathi GP, Radadiya M, Karthik M, Afreen A, Kumaraswamy RC, Va M. A study of clinical and laboratory profile of Dengue fever in tertiary care hospital in central Karnataka, India. Global J Med Res. 2014;14(5).

Ghosh K, Gangodkar S, Jain P, Shetty S, Ramjee S, Poddar P, et al. Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy. J Electron Microsc. 2008;57(3):113-8.

Avarebeel S, Prahlad KA, Tabassum L. Study of clinical and demographic profile of dengue fever. J Evid Based Med Healthcare. 2014;1(4):211-30.

Jayashree K, Manasa GC, Pallavi P, Manjunath GV. Evaluation of platelets as predictive parameters in dengue fever. Indian J Hematol Blood Transfus. 2011;27(3):127-30.

Downloads

Published

2017-05-27

How to Cite

Deshkar, S. T., Raut, S. S., & Khadse, R. K. (2017). Dengue infection in central India: a 5 years study at a tertiary care hospital. International Journal of Research in Medical Sciences, 5(6), 2483–2489. https://doi.org/10.18203/2320-6012.ijrms20172433

Issue

Section

Original Research Articles