Clinico-haematological profile of dengue virus infection at rural tertiary care centre in North India

Authors

  • Vidyasagar Ram Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Khwaja Saifullah Zafar Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Manoj Kumar Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Ganga Prasad Vaishya Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Ejaz Ahmad Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Jay Prakash Pal Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173080

Keywords:

Clinical profile, Dengue fever, Dengue hemorrhagic fever, Haematological profile, Rural area

Abstract

Background: In India, dengue epidemics are becoming more frequent. Dengue viral infections are among the most important mosquito-borne disease of the Indian subcontinent. The study aimed to compare the clinical and haematological profile of all patients diagnosed with dengue viral infection. Patient with confirmed infection with dengue virus were prospectively evaluated for disease progression and to determine their final clinical outcome. The objective of the study was to study the clinico-haematological profile of dengue infection at rural tertiary care centre.

Methods: This prospective study included 456 clinically suspected cases of dengue infection of ages more than 14 years of age. Dengue was confirmed by serological methods. Confirmed cases of dengue infection were analyzed according to age, sex and education. Clinical and hematological data were compared between dengue fever and dengue hemorrhagic fever.

Results: Serologic dengue infection was positive in 220 (48%) out of 456 clinically suspected cases of the dengue infection. 127 (57.73%) patients were males and 93 (42.27%) were females. 149 (67.72%) patient had dengue fever while 71 (32.27%) had dengue hemorrhagic fever. The proportion of dengue cases was highest among male aged 15 to 24 years-old. A gradual decrease occurred in the percentage of dengue cases in the population aged 44 years-old or more. Common clinical symptoms were fever, headache, abdominal pain, myalgia, joint pain and retro-orbital pain. Common haematological abnormalities were thrombocytopenia, leukopenia and elevated alanine aminotransferase (SGOT).

Conclusions: Differences in the clinical, biochemical and haematological profile of dengue virus infection, indicative of a variation in disease severity from DF to DHF. In this study, we present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and earlier appropriate treatment of dengue virus infection.

Author Biographies

Vidyasagar Ram, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

ASSISTANT PROFESSOR,

Department of Medicine,UPUMS,SAIFAI,

ETAWAH,U.P.

Khwaja Saifullah Zafar, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

ASSOCIATE PROFESSOR,

Department of Medicine,UPUMS,SAIFAI,

ETAWAH,U.P.

INDIA

Manoj Kumar, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

PROFESSOR & HEAD

department of medicine,UPUMS,SAIFAI,

ETAWAH,U.P.

INDIA

Ganga Prasad Vaishya, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

PG JUNIOR RESIDENT 3rd year
Department of 
Medicine,UPUMS,SAIFAI,ETAWAH

Ejaz Ahmad, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

PG JUNIOR RESIDENT 3rd year
Department of 
Medicine,UPUMS,SAIFAI,ETAWAH

Jay Prakash Pal, Department of Medicine, UP University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

PG JUNIOR RESIDENT 3rd year
Department of 
Medicine,UPUMS,SAIFAI,ETAWAH

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Published

2017-07-26

How to Cite

Ram, V., Zafar, K. S., Kumar, M., Vaishya, G. P., Ahmad, E., & Pal, J. P. (2017). Clinico-haematological profile of dengue virus infection at rural tertiary care centre in North India. International Journal of Research in Medical Sciences, 5(8), 3329–3333. https://doi.org/10.18203/2320-6012.ijrms20173080

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Section

Original Research Articles