A light microscopic study of placentae in eclamptic mothers at term

Authors

  • Rudradev Meyur Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India
  • Anirban Sadhu Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India
  • Hironmoy Mondal Department of Anatomy, North Bengal Medical College, P.O. Sushruta Nagar, Siliguri, Darjeeling-734012, West Bengal, India
  • Santanu Kumar Khanra Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173987

Keywords:

Eclampsia, Fibrinoid necrosis, Villi

Abstract

Background: Eclampsia is one of the leading causes of maternal and consequent foetal mortality in India. Studies on the histology of eclampsia are relatively uncommon, more so in the eastern region of India. The present study therefore is an attempt to analyse the changes which occur in placentae of eclamptic mothers with the help of light microscope as it is considered to be the epicentre of the disease. These findings are useful to understand the pathology of the killer disease and improve morbidity and mortality.

Methods: 60 cases were selected for the study. 30 were non-eclamptic and 30 were eclamptic. Abnormalities in blood vessels, villi and basement membrane of placentae were searched for after routine H and E staining.

Results: Eclamptic cases recorded with higher incidences of fibrinoid necrosis of villi, cytotrophoblastic proliferation, increased syncytial knots, hypo vascular villi and thickening of basement membrane. Non-eclamptic cases recorded only fibrinoid necrosis. Other features were not observed in the latter cases.

Conclusions: Light microscopic changes observed in eclamptic placentae may contribute to the pathogenesis of the condition and serve as the baseline for further studies.

Author Biographies

Rudradev Meyur, Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India

Associate Professor,

Department of Anatomy,

R G Kar Medical College,

1 Khudiram Bose Sarani,

Kolkata 700004,

West Bengal,

India

 

Anirban Sadhu, Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India

Associate Professor,
Department of Anatomy,
R G Kar Medical College,
1 Khudiram Bose Sarani,
Kolkata 700004,
West Bengal,
 India

 

Hironmoy Mondal, Department of Anatomy, North Bengal Medical College, P.O. Sushruta Nagar, Siliguri, Darjeeling-734012, West Bengal, India

Demonstrator,
Department of Anatomy,
R G Kar Medical College,
1 Khudiram Bose Sarani,
Kolkata 700004,
West Bengal,
 India

Santanu Kumar Khanra, Department of Anatomy, R G Kar Medical College, 1 Khudiram Bose Sarani, Kolkata-700004, West Bengal, India

Demonstrator,
Department of Anatomy,
R G Kar Medical College,
1 Khudiram Bose Sarani,
Kolkata 700004,
West Bengal,
 India

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Published

2017-08-26

How to Cite

Meyur, R., Sadhu, A., Mondal, H., & Khanra, S. K. (2017). A light microscopic study of placentae in eclamptic mothers at term. International Journal of Research in Medical Sciences, 5(9), 4082–4086. https://doi.org/10.18203/2320-6012.ijrms20173987

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Original Research Articles