Thyroid profile in newly diagnosed male HIV patients: a study from North Western part of India

Authors

  • Naresh Kumar Midha Department of General Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
  • Chaudhary M. Department of Paediatrics, Dr. S. N. Medical College Jodhpur, Rajasthan, India
  • Choudhary L. K. Department of General Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
  • Srivastva S. Department of General Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
  • Gupta M. Department of General Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173527

Keywords:

CD4 cell count, Endocrine changes, Hyperthyroidism, Hypothyroidism

Abstract

Background: The aim of this study was to determine proportion of newly diagnosed male HIV cases with thyroid dysfunction at different levels of CD4 counts.

Methods: 195 newly diagnosed male HIV patients attending medical OPD, ART centre and medical wards of SMS Medical College and Hospital, during a period of May 2012 to April 2013 were enrolled in the study. These patients were divided in three groups on the basis of CD4 cell counts. Group A: CD4 counts <200/mm3, Group B: CD4 counts 200-499/mm3 and Group C: CD4 counts >500/mm3.

Results: We concluded a negative correlation between the CD4 counts and serum TSH level (r = -0.382) which was significant (p-value <0.05). Overall 32 (16.41%) patients had increased TSH, 4 (2.05%) patients had decreased and 159 (81.53%) patients had normal TSH level. Plasma TSH values in group A were higher than group B and C and they were highly significant (p<.001). Mean plasma TSH values in patients of group A, B and C was 4.56±3.60 µIU/mL (range: 1.10-17.74), 2.20±1.02 µIU/mL (range:0.24-4.22) and 2.23±1.06 µIU/mL (range:0.28-4.25) respectively. (Reference normal value = 0.4-4.0 µIU/mL). There was significantly positive correlation (p-value < 0.01) found between the CD4 counts and serum free T4 levels (r = +0.378).

Conclusions: This study has demonstrated a high prevalence of thyroid dysfunction in HIV infected patients of this part of country. High prevalence of thyroid dysfunction may contribute to the morbidity of the patients and have a bearing on quality of life of the HIV infected patients. Severity of hypothyroidism was correlated with decreasing CD4 cell count.

Author Biography

Naresh Kumar Midha, Department of General Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India

Senior Resident doctor Department of Internal Medicine

AIIMS Jodhpur

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Published

2017-07-26

How to Cite

Midha, N. K., M., C., K., C. L., S., S., & M., G. (2017). Thyroid profile in newly diagnosed male HIV patients: a study from North Western part of India. International Journal of Research in Medical Sciences, 5(8), 3385–3388. https://doi.org/10.18203/2320-6012.ijrms20173527

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Original Research Articles