Effect of combination of Nigella sativa and Bee’s honey on lung function, respiratory muscle power, and asthma control in patients with persistent asthma

Authors

  • Jehan E. Abdelrahman Faculty of Medicine, National Ribat University, Khartoum, Sudan
  • Aamir A. Magzoub Faculty of Medicine, National Ribat University, Khartoum, Sudan
  • Randa E. Ibrahim Faculty of Medicine, Elimam Elmahdi University, Sudan
  • Mohamed A. Elnoor Faculty of Medicine, National Ribat University, Khartoum, Sudan
  • Omer A. Musa Faculty of Medicine, National Ribat University, Khartoum, Sudan

DOI:

https://doi.org/10.18203/2320-6012.ijrms20164556

Keywords:

Asthma, Asthma control test, Bee's honey, Nigella sativa, Pulmonary function test, Respiratory muscle power

Abstract

Background: Persistent asthma is a serious global medical problem, usually controlled by long term use of inhaled corticosteroids (ICS). However, ICS are expensive particularly in the developing countries and despite their use, a proportion of patients still suffer from uncontrolled symptoms and may progress into intractable airflow limitation. Nigella sativa and Bee’s honey are relatively cheap and safe natural products with anti- inflammatory and anti-allergic properties; they are used traditionally in treatment of so many diseases.

Methods: In this study, we investigated the adjuvant effect of combination of Nigella Sativa and Bee’s honey on lung function, respiratory muscle power and asthma control in patients with persistent asthma. An oral dose of Nigella sativa (2 mg once daily), and bee’s honey (7.5 ml twice a day) were given to patients with uncontrolled persistent asthma (n=30, 14 females and 16 males with mean age of 43.91±5.8) for three months duration. Lung function tests (FEV1, FVC and PEFR) and respiratory muscle power indicators (MEP, MIP) were measured initially as baseline records and monthly for 3 months. The baseline score for asthma control test (ACT) was calculated for all patients and repeated after three months.

Results: There was statistically significant improvement in lung function and respiratory muscle power. The need for asthma relieving β2 agonists was remarkably decreased and a significant improvement in asthma control test score in both asthma groups was observed.

Conclusions: Combination of Nigella sativa and Bee's Honey as an adjuvant therapy with ICS decreases asthma severity grade and hence the need for both asthma controlling and relieving drugs and improves patient’s quality of life.

References

Mark RTZ, Eric D, Louis Ph, et al. What is known about asthma: A Pocket Guide for Physicians and Nurses. 2012;5. www.ginasthma.org.

Anderson, GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008;372:1107-19.

Szefler SJ1, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, et al. Significant variability in response to inhaled corticosteroids forpersistent asthma. J Allergy Clin Immunol. 2002;109:410-8.

Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, et al. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol. 2007;119:73-80.

Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med. 2004;170:836-44.

Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet. 2003;361:1071-6.

Jones PW. Interpreting thresholds for a clinically significant change in health status in asthma and COPD. Eur Respir J. 2002;19:398-404.

Paarakh PM. Nigella sativa Linn. A comprehensive review. Indian J Nat Prod Resour. 2010;1:409-29.

Paul IM, Beiler J, Mc Monagle A, Shaffer ML, Duda L, Berlin CM Jr. Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch. Pediatr. Adolesc. Med. 2007;161(12):1140-6.

Olaitan PB, Adeleke OE, Ola IO. Honey: a reservoir for microorganisms and an inhibitory agent for microbes. Afr. Health Sci. 2007;7(3):159-65.

Cooper R. Using honey to inhibit wound pathogens. Nurs. Times. 2008;104(3):46-9.

Mesaik MA, Azim MK, Mohiuddin S. Honey modulates oxidative burst of professional phagocytes. Phytotherapy Research. 2008;73:2094-6.

Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Alvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci. 2008;73(9):R117-24.

Boskababy MH, sheiravi N. Inhibitory effect of Nigella Sativa on histamine receptors of of isolated guinea pig tracheal chains.pharmaceutical biology. 2002;40(8):596-602.

Ahmed A, Husain A, Mujeeb M. A review on therapeutic potential of Nigella Sativa. Asian Pac J Trop Biomed. 2013;3(5):337-52.

Keyhanmanesh R, Bagban H, Nazemiyeh H, Mirzaei Bavil F, Alipour MR, Ahmady M. The Relaxant Effects of Different Methanolic Fractions of Nigella sativa on Guinea Pig Tracheal Chains. Iran J Basic Med Sci. 2013;16(2):123-8.

Keyhanmanesh R, Boskabady M H, Eslamizadeh M J, Khamneh S, Ebrahimi MA. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs. Planta Med. 2010;76(3):218-22.

Boskabady MH, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad MR. Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. J. Zhejiang Univ. Sci. B. 2011;12(3):201-9.

Miller M, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R et al. ATS/ERS Task Force: Standardization of lung function testing. Euro Respir J. 2005;26(1):153-61.

Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol. 2007;21(5):559-66.

Ameen NMA, Altubaigy F, Jahangir T, Mahday IA, Mohammed EA, Musa OAA. Effect of Nigella sativa and bee honey on pulmonary, hepatic and renal function in Sudanese in Khartoum state. J Med Plants Res. 2011;5(31):6857-63.

Global strategy for asthma management and prevention, 2016. Available at: http://ginasthma.org/ 2016-gina-report-global-strategy-for-asthma-management-and-prevention/.

The WHO Strategy for Traditional Medicine, 2002.Available at: http://apps.who.int/ iris/handle/ 10665/122025. Accessed 2 November 2016.

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Published

2016-12-19

How to Cite

Abdelrahman, J. E., Magzoub, A. A., Ibrahim, R. E., Elnoor, M. A., & Musa, O. A. (2016). Effect of combination of Nigella sativa and Bee’s honey on lung function, respiratory muscle power, and asthma control in patients with persistent asthma. International Journal of Research in Medical Sciences, 5(1), 236–239. https://doi.org/10.18203/2320-6012.ijrms20164556

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Original Research Articles