Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters

Authors

  • Anwar Habib Department of Medicine, HIMSR, Jamia Hamdard, New Delhi, India
  • Razi Ahmad Department of Pharmacology, HIMSR, Jamia Hamdard, New Delhi, India
  • Sana Rehman Department of Pharmacology, HIMSR, Jamia Hamdard, New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20174959

Keywords:

Chronic renal failure, Hematological parameters, Hemodialysis

Abstract

Background: Chronic kidney disease (CRD) is a global public health problem, where slowly progressive deterioration in kidney function lead to numerous hematological and biochemical dysfunction which further make the patients vulnerable to cardiovascular morbidity and mortality if appropriate measures is not taken for their control. The aim of present study was to find out the common hematological dysfunction that may occur in the patients of chronic renal failure (CRF) and in the process of dialysis and suggest appropriate measures for their management.

Methods: Forty-two patient with CRF and on regular maintenance dialysis and 40 healthy adults were recruited into the study. Hemoglobin concentration, total red cell count, total white blood cell count and platelet count and ESR were assessed for the subjects and controls. Results were analyzed using SPSS 21.0 version.

Results: showed that the RBC count, hemoglobin levels and platelets counts are significantly reduced in the patients of chronic renal failure and the process of hemodialysis further decreases the level of all the above mentioned hematological parameters whereas there is slight increase in total leucocyte count but significant increase in ESR was detected.

Conclusions: Chronic renal failure is associated with different degrees of abnormality in hematological parameters that needs careful evaluation and management.

References

National Kidney Foundation: K/DOQI Clinical Practice Guidelines for Anemia of Chronic Kidney Disease. Am J Kidney Dis. 2006;47 (Suppl 3): S33-S53.

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Published

2017-10-27

How to Cite

Habib, A., Ahmad, R., & Rehman, S. (2017). Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters. International Journal of Research in Medical Sciences, 5(11), 4998–5003. https://doi.org/10.18203/2320-6012.ijrms20174959

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Section

Original Research Articles