Retrospective analysis of biochemical profile of dengue infection in a tertiary care hospital

Authors

  • Denesh Narasimhan Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
  • Silpita Katragadda Department of Infectious Disease, Apollo Hospitals, Jubilee Hills, Hyderabad, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20175131

Keywords:

Dengue infection, Elevated liver enzymes, Hypocalcemia

Abstract

Background: Dengue is an exceedingly common infection of the tropics. The aim of the research to study the biochemical parameters of serologically proven dengue cases.

Methods: The study included Dengue patients admitted in PSG Hospital between January 2011and December 2012.

Results: Analysis of aspartate aminotransferase results showed that 19.1% had two-fold rise, 13.3% had three-fold rise and 19.6% had more than threefold rise. Analysis of alanine aminotransferase showed that 35.7% had normal values, 14.95% had two-fold rise, 11.1% had three-fold rise and 11.5% had more than threefold rise. Serum proteins were normal in 35.7% and low in 19.6%. Analysis of serum albumin showed low values in 10.6% Serum sodium levels were low in 11.1% of patients. Albuminuria was positive in 53% of patients. Serum ionised calcium levels were low in 26.8% of patients.

Conclusions: The biochemical abnormalities noted in our study included include elevated liver enzymes, low sodium and ionised calcium levels, hypoalbuminemia and increased urine albumin excretion.

References

World Health Organization. Dengue guidelines for diagnosis, treatment, prevention and control new edition. Geneva, 2009. Available at http://www. who.int/rpc/guidelines/9789241547871/en/.

Souza LJ, Nogueira RM, Soares LC, Soares CE, Ribas BF, Alves FP, et al. The impact of dengue on liver function as evaluated by aminotransferase levels. Braz J Infec Dis. 2007;11(4):407-10.

Nguyen TL, Nguyen TH, Tieu NT. The impact of dengue haemorrhagic fever on liver function. Res virol. 1997;148(4):273-7.

Dahanayaka NJ, Agampodi SB, Arachchi UK, Vithange SP, Rajapakse R, Ranathunga K, et al. Dengue fever and ionized calcium levels: significance of detecting hypocalcaemia to predict severity of dengue. Ceyl Medic J. 2017;62(1).

Brito CA, Albuquerque MD, Lucena-Silva N. Plasma leakage detection in severe dengue: when serum albumin quantification plays a role?. Revista da Sociedade Brasileira de Medicina Tropical. 2007;40(2):220-3.

Rose J, Palanisamy A, Vijayarani H, Anna A. Electrolyte disturbance in Dengue infected patients Internat J Advanc Pharmacy, Biol Chemistr. 2014;3(4):933-6.

Bhagyamma SN, Sreenivasulu U, Shyam Prasad BR, Anuradha R, Durga T. Electrolyte disturbance in dengue infected patients: A hospital based study. Int J Res Health Sci. 2015;3(1):130-3.

Kumar ss, kanna s, palaniandavan s. Assessment of proteinuria for early diagnosis and risk prediction of dengue hemorrhagic fever/dengue shock syndrome in dengue infections. 2017;8(1):440-443.

Vasanwala FF, Thein TL, Leo YS, Gan VC, Hao Y, Lee LK, et al. Predictive value of proteinuria in adult dengue severity. PLoS Neglected Trop Dis. 2014;8(2):e2712.

Mendez A, Gonzalez G. Dengue haemorrhagic fever in children: ten years of clinical experience. Biomedica: revista del Instituto Nacional de Salud. 2003;23(2):180-93.

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Published

2017-11-25

How to Cite

Narasimhan, D., & Katragadda, S. (2017). Retrospective analysis of biochemical profile of dengue infection in a tertiary care hospital. International Journal of Research in Medical Sciences, 5(12), 5218–5220. https://doi.org/10.18203/2320-6012.ijrms20175131

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Section

Original Research Articles