Pediatric papillary thyroid carcinoma successfully managed with a multimodal approach
DOI:
https://doi.org/10.18203/2320-6012.ijrms20175754Keywords:
Children, Multimodal approach, Papillary thyroid carcinoma, Radioiodine (131I) ablationAbstract
Malignant tumours of the thyroid gland are rare in children. The tumours tend to be advanced at the time of presentation, but the overall survival is still better as compared to adults. The use of radioiodine ablation or treatment for the post-thyroidectomy gland remnants or recurrences improves patient survival. The reports of a multimodal approach that involves surgery as the primary treatment along with radioiodine ablation (RIA) are rare in the pediatric age group. We describe here a child with metastatic papillary thyroid carcinoma treated with a multimodal approach.
References
Vaisman F, Corbo R, Vaisman M. Thyroid Carcinoma in Children and Adolescents-Systematic Review of the Literature. J Thyroid Res. 2011;2011:845362.
Park S, Jeong JS, Ryu HR, Lee C-R, Park JH, Kang S-W, et al. Differentiated thyroid carcinoma of children and adolescents: 27-year experience in the Yonsei university health system. J Korean Med Sci. 2013;28:693-9.
Verburg FA, van Santen H, Luster M. Pediatric papillary thyroid cancer: current management challenges. OncoTargets Ther. 2016;10:165-75.
Demidchik YE, Demidchik EP, Reiners C, Biko J, Mine M, Saenko VA, et al. Comprehensive Clinical Assessment of 740 Cases of Surgically Treated Thyroid Cancer in Children of Belarus: Ann Surg. 2006;243:525-32.
Lazar L, Lebenthal Y, Steinmetz A, Yackobovitch-Gavan M, Phillip M. Differentiated Thyroid Carcinoma in Pediatric Patients: Comparison of Presentation and Course between Pre-pubertal Children and Adolescents. J Pediatr. 2009;154:708-14.
Wong KT. Ultrasound of thyroid cancer. Cancer Imaging. 2005;5:157-66.
Dayal D, Prasad R. Congenital hypothyroidism: Current perspectives. Res Rep Endocr Disord. 2015;5:91-102.
Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr Relat Cancer. 2006;13:427-53.
Hay ID, Gonzalez-Losada T, Reinalda MS, Honetschlager JA, Richards ML, Thompson GB. Long-Term Outcome in 215 Children and Adolescents with Papillary Thyroid Cancer Treated During 1940 Through 2008. World J Surg. 2010;34:1192-202.
Samuel AM, Rajashekharrao B, Shah DH. Pulmonary metastases in children and adolescents with well-differentiated thyroid cancer. J Nucl Med. 1998;39:1531-6.
Samuel AM, Sharma SM. Differentiated thyroid carcinomas in children and adolescents. Cancer. 1991;67:2186-90.
Poyrazoğlu Ş, Bundak R, Baş F, Yeğen G, Şanlı Y, Darendeliler F. Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation. J Clin Res Pediatr Endocrinol. 2017;9:185-93.