An unusual adverse event with the use of intravenous bolus of promethazine (phenergan)

Authors

  • Anish Singh Department of Anaesthesia, Max Hospital Patparganj, Delhi, India
  • Mamta Jain Department of Anaesthesia, Pt BDS PGIMS Rohtak, Haryana, India
  • Jai Prakash Department of Anaesthesia, Pt BDS PGIMS Rohtak, Haryana, India
  • Jyoti Sharma Department of Anaesthesia, Pt BDS PGIMS Rohtak, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20175560

Keywords:

Adverse effect, Extravasation, Intravenous promethazine, Tissue necrosis

Abstract

The earlier used sedatives like promethazine, pethidine and pentazocine (fortwin) are not commonly used these days but at times they are used especially in periphery for postoperative sedation and in gynecological surgeries and wards. We hereby report an unusual adverse event associated with the use of intravenous bolus of Promethazine. With this case report we want to highlight that if promethazine is to be used for any purpose it should be given preferably intramuscular and if given intravenously, should be diluted and given slowly in a good running cannula.

 

References

Kulkarni TM. A comparison of three drug combinations for sedation during middle ear surgeries under local anesthesia: a multicentric randomized double blind study. Jr KIMSU. 2015;(4)3.

Cohen M, Stallone F, Pallin DJ. Injectable promethazine: a risky drug of questionable efficacy. Drugs Therapy Perspectives. 2016;32(7):294-6.

Foret AL, Bozeman AP, Floyd WE. Necrosis caused by intra-arterial injection of promethazine: case report. J Hand Surg Am. 2009;34:919-23.

Paula R, Peckler B, Nguyen M, Orban D, Butler T. Catastrophic complications of intravenous promethazine. Am J Emerg Med. 2010;28:535.e1-4.

Grissinger M. Preventing serious tissue injury with intravenous promethazine (phenergan). Pharmacy and Therapeutics. 2009;34(4):175.

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Published

2017-12-23

How to Cite

Singh, A., Jain, M., Prakash, J., & Sharma, J. (2017). An unusual adverse event with the use of intravenous bolus of promethazine (phenergan). International Journal of Research in Medical Sciences, 6(1), 347–348. https://doi.org/10.18203/2320-6012.ijrms20175560

Issue

Section

Case Reports