Histopathological spectrum of neoplastic lesions of female reproductive system-a two-year experience in Eastern Nepal

Authors

  • Mrinalini Singh Department of Pathology, Birat Medical College and Teaching Hospital, Tankisinwari, Morang, Nepal
  • Krishna Kumar Jha Department of Pathology, Birat Medical College and Teaching Hospital, Tankisinwari, Morang, Nepal
  • Prija Poudyal Department of Pathology, Birat Medical College and Teaching Hospital, Tankisinwari, Morang, Nepal
  • Santosh Upadhyay Kafle Department of Pathology, Birat Medical College and Teaching Hospital, Tankisinwari, Morang, Nepal

DOI:

https://doi.org/10.18203/2320-6012.ijrms20180280

Keywords:

Benign tumors, Leiomyoma, Malignant tumors, Squamous cell carcinoma cervix

Abstract

Background: Neoplastic lesions of female reproductive system (FRS) consist majority of surgical cases. The aim of this study is to find out the frequency distribution of tumors occurring in FRS.

Methods: This is a retrospective study carried out in Birat Medical College, situated in eastern Nepal. All formalin fixed surgical specimen of FRS from August 2015 to September 2017 were subjected for histopathology and examined under light microscopy. All neoplastic lesions were included, and non-neoplastic lesions were excluded from the study.

Results: A total number of ninety (90) histopathological tissues representating various types of neoplastic lesion of FRS were studied. Out of which 6 (6.6%) tumors were from uterine cervix, (including 1 cervical leiomyoma and 5 squamous cell carcinoma cervix) 45(50%) tumors were from uterine body, (all leiomyoma) 20 (22.2%) tumors were from ovary (including 9 mature teratoma, 1 immature teratoma, 6 mucinous cystadenoma and 4 cases of serous cystadenoma) and 19 (21.2%) tumors were from breast (including 16 fibroadenoma, 1 lactational adenoma, 2 infiltrating ductal carcinoma and 1 comedo carcinoma). Majority 81(90%) were benign and 9 (10%) were malignant. Most common benign tumor was leiomyoma of uterine body and most common malignant tumor was squamous cell carcinoma of uterine cervix both commonly occurring in the age group of 41-50 years.

Conclusions: Benign tumor, leiomyoma is the common tumor occurring in FRS. Carcinoma of the cervix is the common malignant tumor.

References

Stewart BW, Kleihues P (Eds.). Cancers of the female reproductive tract. In: World Cancer Report. Lyon, France: IARC Press;2003.

Boosz AS, Reimer P, Matzko M, Romer T, Muller A. The conservative and interventional treatment of fibroids. Dtsch Arztebl Int. 2014;111:877-83.

Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111:1037-54.

Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynaecol. 2003;188:100-7.

Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. Association of physical activity with development of uterine leiomyoma. Am J Epidemiol. 2007;165:157-63.

Lurie S, Piper I, Woliovitch I, Glezerman M. Age-related prevalence of sonographicaly confirmed uterine myomas. J Obstet Gynaecol. 2005;25:42-4.

Haque R, Tyagi SP, Khan MH, Gahlaut YVS. Breast lesions. A clinicopathological study of 200 cases of breast lumps. Ind J Surg. 1980;42:419-25.

Oluwole SF, Freeman HP. Analysis of benign breast lesions in blacks. Ame J Surg. 1979;137(6):786-9.

Thanikasalam K, Ho CM, Adeed N, Shahidan MN, Azizah WK. Links pattern of ovarian tumours among Malaysian women at general hospital, Kuala Lumpur. Med J Malaysia. 1992;47:139-46.

Scully RE, Clement PB, Young RH. Ovarian surface epithelial stromal tumors. In: Carter D, Greenson JK, Oberman HA, Reuter V,Stoler MH, editors. Sternberg’s Diagnostic Surgical pathology. 4thed. Lippincott Williams and wilkins: Philadelphia; 2004:2543-73.

Scully RE, Young RH, Clement PB. Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament. Inter J Gynecol Pathol. 1999;18(3):288.

Zaloudek C. tumors of the ovary. In: Fletcher CDM, editor. Diagnostic histopathology of tumors. 2nd ed. Churchill Livingstone, Philadelphia;2005:567-641.

Schottenfeld D, Fraumeni Jr JF, editors. Cancer epidemiology and prevention. Oxford University Press; 2006.

Oeffinger KC, Fontham ET, Etzioni R, Herzig A, Michaelson JS, Shih YC, et al. Breast cancer screening for women at average risk: 2015 guideline update from the American Cancer Society. Jama. 2015;314(15):1599-614.

Dieci MV, Orvieto E, Dominici M, Conte P, Guarneri V. Rare breast cancer subtypes: histological, molecular, and clinical peculiarities. Oncologist. 2014;19:805-13.

Tamimi RM, Colditz GA, Hazra A, Baer HJ, Hankinson SE, Rosner B, et al. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat. 2012;131:159-167.

Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70.

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Published

2018-01-24

How to Cite

Singh, M., Jha, K. K., Poudyal, P., & Kafle, S. U. (2018). Histopathological spectrum of neoplastic lesions of female reproductive system-a two-year experience in Eastern Nepal. International Journal of Research in Medical Sciences, 6(2), 426–430. https://doi.org/10.18203/2320-6012.ijrms20180280

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Original Research Articles