Visual evoked potentials in children with type 1 diabetes mellitus

Authors

  • Meenal Batta Department of Physiology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Rajeev Sharma Department of Physiology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Naveenta Gupta Department of Physiology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Sonia Garg Department of Physiology, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Gurmeet Kaur Department of Pediatrics, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Shashi Kant Dhir Department of Pediatrics, Guru Gobind Singh Medical College, Faridkot, Punjab, India
  • Amarpreet Kaur Department of Pediatrics, Guru Gobind Singh Medical College, Faridkot, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20181016

Keywords:

Children, Type 1 diabetes mellitus, Visual evoked potentials

Abstract

Background: Insulin-dependent (type 1) diabetes mellitus is associated with different degrees of neuropathies affecting peripheral as well as central neural pathways. The subclinical neurological involvement in diabetic children can be assessed by changes appearing in the electrophysiological parameters like Visual Evoked Potentials (VEPs). The objective of the study was to assess the effect of type I diabetes melitus on the visual evoked potentials in children.

Methods: This cross-sectional case-control study was done on 30 children with type 1 diabetes mellitus of minimum two years duration as cases and 30 age and gender matched euglycemic children with normal HbA1c taken as controls. Visual Evoked Potentials (VEPs) were done on both the groups of children and the latencies (ms) of waves -N75, P100, N145 and amplitude (μV) of wave P100 were recorded. The data was compiled in the pre-designed proforma and statistically analysed using student t-test.

Results: The increase in the mean latencies of waveforms of VEPs N75, P100 and amplitude P100 were found to be highly significant statistically (p<0.001) in both the eyes among the children with type 1 diabetes mellitus. The mean latency of waveform N145 was found to be statistically insignificant in the two groups (p>0.05).

Conclusions: The type 1 diabetes does affect the visual pathways in children. Visual Evoked Potentials are helpful in the detection of early changes in the conduction across the neural pathways in the sub-clinical diseases.

References

Sinnreich M, Taylor BV, Dyck PJB. Diabetic neuropathies. Classification, clinical features, and pathophysiological basis. Neurologist. 2005;11(2):63-79.

Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Dia Metab. 1977;3(2):97-107.

Tesfaye S, Boulton AJM, Dyck PJ, Freeman R, Horowitz M, Kempler P, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285-93.

Dyck PJ, Albers JW, Andersen H, Arezzo JC, Biessels G-J, Bril V, et al. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011;27(7):620-8.

Batta M, Dhir SK. Assessment of auditory function by brainstem auditory evoked response in children having type 1 diabetes mellitus. Sub Him J Heal Res. 2016;3:52-5.

Puvanendran K, Devathasan G, Wong PK. Visual evoked responses in diabetes. J Neurol Neuro Surg Psychiatry. 1983;46(7):643-7.

Mukartihal GB, Radhakrishnan S. Design and development of visual evoked potentials recording system for diagnosis of optic nerve diseases. J Instrum Soc Ind. 2006;36(4):227-34.

American Diabetic Association. Classification and Diagnosis of Diabetes. Diabetes Care. 2015;38(1):S8-16.

Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Mizota A, et al. ISCEV standard for clinical visual evoked potentials: (2016 update). Doc Ophthalmol Adv Ophthalmol. 2016;133(1):1-9.

Karlica D, Galetović D, Ivanisević M, Skrabić V, Znaor L, Jurisić D. Visual evoked potential can be used to detect a prediabetic form of diabetic retinopathy in patients with diabetes mellitus type I. Coll Antropol. 2010;34(2):525-9.

Fierro B, Meli F, Brighina F, Cardella F, Aloisio A, Oliveri M, et al. Somatosensory and visual evoked potentials study in young insulin-dependent diabetic patients. Electromyogr Clin Neurophysiol. 1996;36(8):481-6.

Seidl R, Birnbacher R, Hauser E, Bernert G, Freilinger M, Schober E. Brainstem auditory evoked potentials and visually evoked potentials in young patients with IDDM. Diabetes Care. 1996;19(11):1220-4.

Anastasi M, Lauricella M, Giordano C, Galluzzo A. Visual evoked potentials in insulin-dependent diabetics. Acta Diabetol Lat. 1985;22(4):343-9.

Uccioli L, Parisi V, Monticone G, Parisi L, Durola L, Pernini C, et al. Electrophysiological assessment of visual function in newly-diagnosed IDDM patients. Diabetologia. 1995;38(7):804-8.

Lee SS, Han HS, Kim H. Visual-evoked potentials in children and adolescents with newly diagnosed diabetes. Turk Pediatri Arsivi. 2017;52(3):133-7.

Matanovic D, Popovic S, Parapid B, Petronic I, Cirovic D, Nikolic D. Influence of the metabolic control on latency values of visual evoked potentials (VEP) in patients with diabetes mellitus type 1. Arch Ital Biol. 2012;150(4):251-8.

Parisi V, Uccioli L, Parisi L, Colacino G, Manni G, Menzinger G, et al. Neural conduction in visual pathways in newly-diagnosed IDDM patients. Electro Clin Neurophysiol. 1998;108(5):490-6.

Cameron NE, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetol. 2001;44:1973-88.

Downloads

Published

2018-03-28

How to Cite

Batta, M., Sharma, R., Gupta, N., Garg, S., Kaur, G., Dhir, S. K., & Kaur, A. (2018). Visual evoked potentials in children with type 1 diabetes mellitus. International Journal of Research in Medical Sciences, 6(4), 1165–1168. https://doi.org/10.18203/2320-6012.ijrms20181016

Issue

Section

Original Research Articles