Posterior reversible encephalopathy syndrome in a patient with underlying mixed connective tissue disease

Authors

  • Malyaban Das Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
  • Prajit Mazumdar Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
  • Divakar Kumar Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
  • Vaibhav Mathur Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20182819

Keywords:

Mixed connective tissue disease (MCTD), Posterior reversible encephalopathy syndrome (PRES), Vasogenic oedema

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a condition which is characterized by symmetric involvement of posterior white matter on brain imaging and neurological impairments such as seizures, altered mental status, headache, and visual disturbances. This entity has been classically described with hypertension, renal failure and eclampsia but it can also been seen in cases with normal blood pressure especially in patients receiving immunosuppressive therapy, chemotherapy and in patients with underlying autoimmune disease. Although PRES has been reported with several autoimmune disorders, association of Posterior reversible encephalopathy syndrome (PRES) with mixed connective tissue disease (MCTD) is very rare, hence we report a case of Posterior reversible encephalopathy syndrome in a patient with underlying mixed connective tissue disease (MCTD).

References

Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494-500.

Bartynski WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol. 2008;29(6):1043-9.

Bartynski WS. Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. AJNR Am J Neuroradiol. 2008;29(6):1036-42.

Amigues JM, Cantagrel A, Abbal M, Mazieres B. Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. autoimmunity group of the hospitals of toulouse. J Rheumatol. 1996;23(12):2055-62.

Liman TG, Bohner G, Heuschmann PU, Endres M, Siebert E. The clinical and radiological spectrum of posterior reversible encephalopathy syndrome: the retrospective Berlin PRES study. J Neurol. 2012;259(1):155-64.

Bartynski WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol. 2008;29(6):1043-9.

Ortega-Hernandez OD, Shoenfeld Y. Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment. Best Pract Res Clin Rheumatol. 2012;26(1):61-72.

Soltesz P, Bereczki D, Szodoray P, Magyar MT, Der H, Csipo I, et al. Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease. Arthritis Res Ther. 2010;12(3):R78.

Stacher G, Merio R, Budka C, Schneider C, Smolen J, Tappeiner G. Cardiovascular autonomic function, autoantibodies, and esophageal motor activity in patients with systemic sclerosis and mixed connective tissue disease. J Rheumatol. 2000;27(3):692-7.

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Published

2018-06-25

How to Cite

Das, M., Mazumdar, P., Kumar, D., & Mathur, V. (2018). Posterior reversible encephalopathy syndrome in a patient with underlying mixed connective tissue disease. International Journal of Research in Medical Sciences, 6(7), 2551–2553. https://doi.org/10.18203/2320-6012.ijrms20182819

Issue

Section

Case Reports