Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study

Authors

  • Laxma Reddy S. Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Ravicharan Avala Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Rajshekar Varma Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Narendrakumar Narahari Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Bhaskar K. Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Paramjyothi G. K. Department of Pulmonary Medicine, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20182824

Keywords:

COPD, FEV1, Vitamin D

Abstract

Background: Vitamin D deficiency is common all over the Indian subcontinent, with a prevalence of 70-100% in the general population. Vitamin D deficiency has a role in several diseases of the respiratory system including chronic obstructive pulmonary disease (COPD). Studies have shown that vitamin D deficient COPD patients have lower lung function measured by FEV1. We conducted a study to see prevalence of Vitamin D deficiency in COPD patients and it’s correlation with Forced Expiratory Volume in 1 second.

Methods: A cross sectional observational study was performed in a tertiary care hospital in Hyderabad, Telangana during the period of one and half year. This included 104 COPD cases attending outpatient department of pulmonary medicine. Serum vitamin D levels were measured, and spirometry was done in all patients and data was analyzed accordingly.

Results: Among 104 patients, 87 were males and 17 were females. Most of the study population (44.2%) was aged between 60-70 years. Mean BMI was 26.40 (±5.77) kg/m2. Majority of study populations (66.34%) were in GOLD stage 1 and 2. The mean Vitamin D value of the study population was 20.77±11.74ng/ml. Majority of the COPD patients were vitamin D deficient (69.2%). 25.0 % was severely deficient of vitamin D. The mean FEV1 volume (%) was 83.15±11.53, 60.97±17.47, 30.71±7.96 in sufficient, deficient and severe deficient patients.

Conclusions: Vitamin D deficiency is common in COPD patients. Serum vitamin D deficiency increases with increased severity of COPD. There is positive correlation between serum vitamin D levels and post bronchodilator FEV1 (%).

 

References

Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics. 2003;112(2):e132-5.

Ritu G, Gupta A. Vitamin D Deficiency in India: Prevalence, causalities and interventions nutrients. 2014;6(2):729-75.

Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006 Mar;81(3):353-73.

Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutri. 2008;87:1080S-6S.

Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81.

Black PN, Scragg R. Relationship between serum 25- hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey. Chest. 2005;128:3792-8.

Searing DA, Leung DY. Vitamin D in atopic dermatitis, asthma and allergic diseases. Immunol Allergy Clin North Am. 2010;30:397-409.

Mahon BD, Wittke A, Weaver V, Cantorna MT. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem. 2003;89:922-32.

Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-10-secretingregulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest. 2006;116:146-55.

DeSmet K, Contreras R. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett. 2005;27:1337-47.

Forli L, Bjortuft O, Boe J. Vitamin D status in relation to nutritional depletion and muscle function in patients with advanced pulmonary disease. Exp Lung Res. 2009;35:524-38.

Hopkinson NS, Li KW, Kehoe A, Humphries SE, Roughton M, Moxham J, et al. Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. Am J Clin Nutr. 2008;87:385-90.

Burns JSDD, Speizer FE. Low levels of dietary vitamin D intake and pulmonary function in adolescents (abstract). Proc Am Thoracic Soc. 2006;3:A536.

Janssens W, Bouillon R, Claes B, Carremans C, Lehouck A, Buysschaert I, et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax. 2010;65:215-20.

Ferrari M, Schenk K, Papadopoulou C, Ferrari P, Dalle Carbonare L, Bertoldo F. Serum 25-hydroxy vitamin D and exercise capacity in COPD. Thorax. 2011 Jun 1;66(6):544-5.

Janssens W, Lehouck A, Carremans C, Bouillon R, Mathieu C, Decramer M. Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. Am J Respir Crit Care Med. 2009;179:630-6.

Zhang P, Luo H, Zhu Y. Prevalence of vitamin D deficiency and impact on quality of life in patients with chronic obstructive pulmonary disease. Zhong nan da xue xue bao. Yi xue ban= J Central South University. Medical sciences. 2012 Aug;37(8):802-6.

Gouda E, Zidan M, Gharraf H, Younan DN, Mohamed S. Pattern of vitamin D in patients with chronic obstructive pulmonary diseases and in patients with bronchial asthma. Egyptian J Chest Diseases and Tuberculosis. 2016 Apr 1;65(2):389-96.

Tedd H, Conroy K, Mitchell A, Shanshal Y, Curtis H. P91 High prevalence of vitamin d deficiency amongst patients with copd in the north east. highlighting a deficiency and need for improved assessment. 2017;72:A132-3.

Zhu M, Wang T, Wang C, Ji Y. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. International J chronic obstructive pulmonary disease. 2016;11:2597.

Mohanta PC, Dutta P, Manji R, Pothal S. Correlation between serum vitamin d level and pulmonary function (FEV1) in patients with chronic obstructive pulmonary disease (COPD). Int J Adv Res. 2016;4(9):1872-8.

Monadi M, Heidari B, Asgharpour M, Firouzjahi A, Monadi M, Mirsaied MA. Relationship between serum vitamin D and forced expiratory volume in patients with chronic obstructive pulmonary disease (COPD). Caspian J internal Med. 2012;3(3):451-5.

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Published

2018-06-25

How to Cite

S., L. R., Avala, R., Varma, R., Narahari, N., K., B., & G. K., P. (2018). Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study. International Journal of Research in Medical Sciences, 6(7), 2396–2400. https://doi.org/10.18203/2320-6012.ijrms20182824

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Original Research Articles