Pattern of neoplastic and non-neoplastic lesions of ovary: a five-year study in a tertiary care centre of rural india

Authors

  • Geeta Maurya Department of Pathology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Sanjeev Kumar Singh Department of Pathology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Pinki Pandey Department of Pathology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Vineet Chaturvedi Department of Pathology, U.P. University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20182828

Keywords:

Germ cell tumours, Ovarian tumours, Ovarian cyst, Surface epithelial tumours

Abstract

Background: Most common ovarian lesions include benign non-neoplastic lesions including functional cysts and neoplastic lesions. While among cancers of female genital tract, the incidence of ovarian cancer ranks below only carcinoma of cervix and endometrium. The aim of this study was to observe and evaluate the frequency and morphological pattern of different ovarian pathologies encountered in this tertiary care centre of rural India.

Methods: This was a retrospective five years observational study (2012-16) and conducted at Department of Pathology of UPUMS, Saifai. The study material included 264 histopathology specimens received in our department.

Results: Total 264 cases of ovarian pathologies were studied, in which 147 cases were non-neoplastic while remaining 117 cases were neoplastic. The most common non-neoplastic lesion was follicular cyst (51.7%), followed by corpus luteal cyst (30.61%), endometriosis (15.64%). Among 117 neoplastic cases, 87 cases (74.35%) were benign, 5 cases (4.27%) were borderline tumours and 25 cases (21.36%) were diagnosed malignant. Serous cystadenoma was most common benign tumour with 53 cases (45.29%) followed by 20 cases (17.09%) of dermoid cyst and 12 cases (10.25%) of mucinous cystadenoma. While in malignant tumours, serous adenocarcinoma were most common (4.27%) followed by mucinous adenocarcinoma (2.56%).

Conclusions: In our study, non-neoplastic ovarian lesions were more commonly seen than neoplastic lesions. Surface epithelial tumours were most common histologic type in all age groups. While serous adenocarcinoma was most common ovarian malignancy seen. Both non-neoplastic as well as neoplastic lesions of ovary often present with similar clinical and radiological features. So histopathological study is essential to diagnose ovarian tumours.

 

References

Ellenson LH, Pirog EC: The female genital tract. Kumar V, Abbas AK, Fausto N, Aster JC. (Eds): Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, Elsevier Saunders. 2010:1039-1052.

Sharma I, Sarma U, Dutta UC. Pathology of ovarian tumour- A hospital-based study. Int J of Med Sci Clin Invention. 2014;1:284-6.

Parkin DM, Bray F, Ferlay J, Pisani P. Global Cancer Statistics, 2002. CA Cancer J Clin. 2005;55:74-108.

Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Changing trends in incidence of ovarian cancer-the Indian scenario. Asian Pac J cancer prev. 2009 Jan 1;10(6):1025-30.

Nishal AJ, Naik KS, Modi J. Analysis of spectrum of ovarian tumours: A study of 55 cases. Int J Res Med Sci. 2015;3:2714-7.

Kuladeepa AV, Muddegowda PH, Lingegowda JB, Doddikoppad MM, Basavaraja PK, Hiremath SS. Histomorphological study of 134 primary ovarian tumors. Ad Lab Med Inter. 2011;1(4):69-82.

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA: a cancer J clinicians. 2008 Mar 1;58(2):71-96.

Cannistra SA. Cancer of the ovary. N Engl J Med. 2004;351:2519-29.

Tavassoli FA, Devilee P (eds). World Health Organizatyion Classification of tumours. Pathology and Genetics. tumours of the breast and female genital organs. Lyon: IARC Press, France;2003.

Kurman RJ, Norris HJ. Malignant germ cell tumours of the ovary. Hum Pathol. 1977;8:551-64.

Martinez-Onsurbe P, Villaespesa AP, Anquela JMS. Aspiration cytology of 147 adnexal cysts with histologic correlation. Acta Cytol. 2001;45:941-7.

Kreuzer GF, Parodowski T, Wurche KD, Flenker H. Neoplastic or non-neoplastic ovarian cyst, the role of cytology. Acta Cytol. 1995;39:882-6.

Kanthikar SN, Dravid NV, Deore PN, Nikumbh DB, Suryawanshi KH. Clinico-histopathological analysis of neoplastic and non-neoplastic lesions of the ovary: a 3-year prospective study in Dhule, North Maharashtra, India. JCDR. 2014;8(8):FC04.

Malaviya AK. Non-neoplastic cysts of ovary- unusual presentations. Indian J Pathol Microbiol. 2001;44:211-45.

Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour like lesions. Indian J Pathol Microbiol. 2007;50:525-7.

Carey M, Krik ME. Necrotic pseudoxanthomatous nodules of the omentum and peritoneum: A peculiar reaction to endometriotic cyst contents. Obstet Gynecol. 1993;82:650-2.

Clement PB, Young RH, Scully RE. Necrotic pseudoxanthomatous nodules of ovary and peritoneum in endometriosis. Am J Surg Pathol. 1988;12:390-7.

Al-Fozan H, Tulandi T. Left lateral predisposition of endometriosis and endometrioma. Obstet Gynecol. 2003;101:164-6.

Tejeswini V, Reddy ES, Premalatha P, Vahini G. Study of morphological patterns of ovarian neoplasms. J Dental Medical Sci. 2013;10:11-6.

Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological pattern of neoplastic ovarian lesions. International Archives integrated Med. 2016;3:51-7.

Ahmad Z, Kayani N, Hasan SH, Muzaffar S et al. Histologic pattern of ovarian neoplasms. J Pak Med Assoc. 2000;50:416-9.

Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. J Cancer Res Therapeutics. 2011 Oct 1;7(4):433.

Bhuvanesh U, Logambal A. Study of ovarian tumours. J Obstet Gynaecol India. 1978;28:271-7.

Pilli G, Sunita KP, Dhaded AV. Ovarian tumours: A study of 282 cases. JIMA. 2002;100:1-6.

Patil RK, Bhandari BJ, Kittur SK, Haravi RM, Aruna S, Jadhav MN. Histomorphological study of ovarian tumors: at a tertiary care centre. Annals Pathol Lab Med. 2017 Dec 18;4(6):A638-645.

Singh S, Saxena V, Khatri SL, Gupta S, Garewal J, Dubey K. Histopathological evaluation of ovarian tumours. Imperial J Interdisciplinary Res. 2016;2:435-9.

Downloads

Published

2018-06-25

How to Cite

Maurya, G., Singh, S. K., Pandey, P., & Chaturvedi, V. (2018). Pattern of neoplastic and non-neoplastic lesions of ovary: a five-year study in a tertiary care centre of rural india. International Journal of Research in Medical Sciences, 6(7), 2418–2422. https://doi.org/10.18203/2320-6012.ijrms20182828

Issue

Section

Original Research Articles