DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20185359

Correlation between 6-minute walk distance and spirometry parameters in stable chronic obstructive pulmonary disease patients

Ruchita B. Hajare, Raziya Nagarwala, Ashok Shyam, Parag Sancheti

Abstract


Background: Six minute walk test (6MWT) is a sub-maximal exercise test, used as a clinical indicator of the functional capacity, in patients with cardiopulmonary diseases. It is simple, objective and reproducible test. The present study was designed to assess correlation of six minute walk test with spirometry parameters, in patients with chronic obstructive pulmonary disease.

Methods: In this cross sectional study, fifty patients diagnosed with chronic obstructive pulmonary disease (GOLD criteria) coming to tertiary center were recruited according to inclusion and exclusion criteria. All patients underwent spirometric measurement. Spirometric indices including FEV1, FVC, FEV1/FVC and MVV were tested using computerized spirometer. 6MWT was performed following American Thoracic Society (ATS) guidelines. Percent (%) predicted 6MWD was calculated. Correlation between spirometry and 6MWT was assessed.

Results: It was found that correlation between 6MWT and spirometry is statistically significant. There is significant strong positive correlation between percent predicted 6MWD and FEV1 (r=0.850 and p= <0.001), whereas there is significant moderate correlation between percent predicted 6MWD and FVC (r=0.554 and p= <0.001), FEV1/FVC (r=0.509 and p= <0.001) and MVV (r=0.615 and p= <0.001).

Conclusions: In chronic obstructive pulmonary disease, percent predicted 6mwd significantly correlated with the spirometry parameters (FEV1, FVC, FEV1/FVC, and MVV). 6MWD decreases as there is decline in the pulmonary function. 6MWT can be a useful replacement of spirometry in assessment of severity of COPD.


Keywords


6MWD, COPD, PFT

Full Text:

PDF

References


Barnes PJ. Chronic obstructive pulmonary disease: A growing But Neglected Global epidemic. Plos Med. 2007;4(5):e112.

Watz H, Magnussen H. Comorbidities of COPD. Internist (Berl). 2006;47(9):895-6.

The Official statement of the American thoracic society, approved by the American thoracic society board of directors 2002. Am J Respir Crit Care Med. 2002;166:111-7.

Di Marco F, Terraneo S, Roggi MA, Repossi AC, Pellegrino GM, Veronelli A, et al. Physical activity impairment in depressed COPD subjects. Res Care. 2014 May 1;59(5):726-34.

Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary exercise testing. Am J Res Crit Care Med. 2000 Feb 1;161(2):487-92.

Chetta A, Aiello M, Foresi A, Marangio E, D'Ippolito R, Castagnaro A, et al. Relationship between outcome measures of six-minute walk test and baseline lung function in patients with interstitial lung disease. Sarcoidosis, vasculitis, and diffuse lung diseases: J WASOG. 2001 Jun;18(2):170-5.

Eaton T, Young P, Milne D, Wells AU. Six-minute walk, maximal exercise tests: reproducibility in fibrotic interstitial pneumonia. Am J Respir Crit Care Med. 2005;171(10):1150-57.

Andrzejczak-Karbowska M, Kapusta J, Inman M, Kowalski J, Irzmański R. Evaluation of the effectiveness of exercise-based controlled physical effort in women with heart failure in the elderly. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego. 2015 Jan;38(223):11-5.

Dajczman E, Wardini R, Kasymjanova G, Préfontaine D, Baltzan MA, Wolkove N. Six minute walk distance is a predictor of survival in patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Canadian respiratory journal. 2015;22(4):225-9.

ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111-7.

Ramanathan RP, Chandrasekaran B. Reference equations for 6-min walk test in healthy Indian subjects (25-80 years). Lung India: official organ of Indian Chest Society. 2014 Jan;31(1):35.

Agrawal MB, Awad NT. Correlation between Six minute walk test and spirometry in chronic pulmonary disease. JCDR. 2015 Aug;9(8):OC01.

Al Ameri H. Six minute walk test in respiratory diseases: A university hospital experience. Annals of Thoracic Medicine. 2006 Jan 1;1(1).

Watz H, Waschki B, Boehme C, Claussen M, Meyer T, Magnussen H. Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study. Am J Res Crit Care Med. 2008 Apr 1;177(7):743-51.

Ernard S, Leblanc P, Whittom F, Carrier G, Jobin J, Belleau R, Maltais F. Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158:629-634.

Gosker HR, Engelen MP, van Mameren H, van Dijk PJ, van der Vusse GJ, Wouters EF, et al. Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutri. 2002;76:113-9.

Similowski T, Agustí A, MacNee W, Schönhofer B. The potential impact of anaemia of chronic disease in COPD. Euro Respir. J 2006;27:390-6.

Kim HC, Mofarrahi M, Hussain SN. Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3:637-58.

Davidson AC, Leach R, George RJ, Geddes DM. Supplemental oxygen and exercise ability in chronic obstructive airways disease. Thorax. 1988;43:965-71.

Kent BD, Mitchell PD, McNicholas WT. Hypoxemia in patients with COPD: cause, effects, and disease progression. Inter J Chron Obst Pul Dis. 2011;6:199-208.

O’Donnell DE, Webb KA. The major limitation to exercise performance in COPD is dynamic hyperinflation. J Appl Physiol. 2008;105:753-5.

Tantucci C. Expiratory flow limitation definition, mechanisms, methods, and significance. Pul Med. 2013;2013:749860.

O’Donnell DEOD, Laveneziana P. Patterns of cardiopulmonary response to exercise in lung diseases; 2007.

Panagiotou M, Vogiatzis I, Kastanakis E. Exercise Limitation in COPD. Pneumon. 2013;26(3):245-56.

Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest 2001;119:256-70.

Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532-55.